Results 101 to 110 of about 161,478 (359)

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

Advanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol, Pascal Benkert, Sabine Schaedelin, Mario Ocampo‐Pineda, Noemi Montobbio, Po‐Jui Lu, Batuhan Ayci, Antonia Wenger, Alfi Aran Shukur, Kornelius Kaim, Lester Melie‐Garcia, Matthias Weigel, Alessio Signori, Pasquale Calabrese, Ludwig Kappos, Maria Pia Sormani, Jens Kuhle, Cristina Granziera   +17 more
wiley   +1 more source

Establishment of Age- and Sex-Specific Reference Cerebral Ventricle Volumes. [PDF]

World Neurosurg, 2023
Kellogg RT, Park MS, Snyder MH, Marino A, Patel S, Feng X, Vargas J.   +6 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Volumetric measurement of cranial cavity and cerebral ventricular system with 3D Slicer software based on CT data

BMC Medical Imaging
Objective This study aims to evaluate the clinical utility of using 3D Slicer software for volumetric measurement of the cranial cavity and cerebral ventricular system, particularly in hydrocephalus patients. We also provide detailed steps for performing
Yanming Huang, Junxiang Huang, Celin Guan, Tianqing Liu, Shuanglin Que   +4 more
doaj   +1 more source

C.T Scan Measurements of the Lateral and Third Ventricles in Apparently Normal Iraqi Subjects

مجلة كلية الطب, 2009
Background: Cerebral ventricular enlargement has been associated with many neurological disorders. Whether this enlargement is primary or secondary to these pathological conditions remains controversial.
Zauhair A. Jaumah, Fadhil A. AL-Kafhaji
doaj   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

The relationship between the state of cerebral blood flow and volemic status in patients with ischemic stroke in the acute period

Вестник анестезиологии и реаниматологии
The objective was to assess the relationship between the state of cerebral blood flow and volemic status in patients with acute ischemic stroke using the laboratory and instrumental parameters.Materials and methods.
E. V. Mikhailov, I. N. Pasechnik, G. V. Korochkina   +2 more
doaj   +1 more source

Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia

Neural Regeneration Research, 2016
Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic stage of cerebral ischemia.
Wang-shu Xu, Xuan Sun, Cheng-guang Song, Xiao-peng Mu, Wen-ping Ma, Xing-hu Zhang, Chuan-sheng Zhao   +6 more
doaj   +1 more source

Artificial intelligence for automatic cerebral ventricle segmentation and volume calculation: a clinical tool for the evaluation of pediatric hydrocephalus. [PDF]

J Neurosurg Pediatr, 2021
Quon JL, Han M, Kim LH, Koran ME, Chen LC, Lee EH, Wright J, Ramaswamy V, Lober RM, Taylor MD, Grant GA, Cheshier SH, Kestle JRW, Edwards MSB, Yeom KW.   +14 more
europepmc   +1 more source

Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus. [PDF]

, 2019
Though congenital hydrocephalus is heritable, it has been linked only to eight genes, one of which is MPDZ Humans and mice that carry a truncated version of MPDZ incur severe hydrocephalus resulting in acute morbidity and lethality.
Byrne, Matthew D., Horowitz, Arie, Ishikawa, Hiroshi, Kilker, Robert, Londin, Eric, Nichtova, Zuzana, Oakley, Laura, Pardeep-Kumar, Fnu, Pickup, Stephen, Saugier-Veber, Pascale, Schroten, Horst, Simonneau, Claire, Smeyne, Richard, Stefanescu, Ioana, Thakur, Mathew, Tripathi, Sushil, Willard, Belinda, Yang, Junning   +17 more
core   +2 more sources