Results 41 to 50 of about 37,788 (184)

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Interference Control Modulations Over Conscious Perception

Frontiers in Psychology, 2017
The relation between attention and consciousness has been a controversial topic over the last decade. Although there seems to be an agreement on their distinction at the functional level, no consensus has been reached about attentional processes being or
Itsaso Colás, Mónica Triviño, Mónica Triviño, Ana B. Chica   +3 more
doaj   +1 more source

Las repercusiones de la Dislexia en la Autoestima, en el Comportamiento Socioemocional y en la Ansiedad en Escolares

Psicología Educativa: Revista de los Psicólogos de la Educación, 2020
Más allá de las repercusiones neurobiológicas, cognitivas y académicas que acarrea la dislexia, se conocen poco las consecuencias en otras dimensiones del desarrollo humano, como las emocionales y de comportamiento socioemocional.
Linda Zuppardo, Antonio Rodríguez Fuentes, Concetta Pirrone, Francisca Serrano   +3 more
doaj   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

CEREBRO-CEREBELLAR ATAXIA [PDF]

The Journal of Nervous and Mental Disease, 1916
n ...
openaire   +2 more sources

The petrotympanic canal (Huguier canal): Evolutionary, anatomical, and medical perspectives

The Anatomical Record, EarlyView.
Abstract The petrotympanic canal, traditionally referred to as Civinini's or Huguier's canal, represents an anatomical passage connecting the middle ear and temporomandibular joint (TMJ). Despite its early description, its structural complexity and functional significance have often been underestimated. In this study, we combined historical, anatomical,
Andrea Papini, Nicola Montemurro, Ferdinando Paternostro, Immacolata Belviso, Massimo Galli, Petra Martini, Licia Uccelli, Jacopo Moggi‐Cecchi, Gregorio Oxilia   +8 more
wiley   +1 more source

Adolescents views of an unequal world: understanding economic inequality and factors for its reduction

Psychology, Society & Education
Economic inequality has a huge impact on well-being, also affecting adolescents, who are the future agents of our societies. Nevertheless, research often overlooks their perspectives on economic inequality, poverty, and their attitudes towards its ...
Sofía Schwartz-Salazar, Rocío Martínez, Rosa Rodríguez-Bailón   +2 more
doaj   +1 more source

Desarrollo mecánico y experimental de un implante discal cervical flexible

Anales de la Facultad de Medicina, 2019
Introducción: La artroplastía cervical es una cirugía que implica el uso de implantes discales con la capacidad de conservar el movimiento del segmento.
Carlos Alvarez, Paul Lean, Rodolfo Rodríguez, Claudio Pacussich, Ainsworth Noriega, Erick Navarro   +5 more
doaj   +1 more source

Supratherapeutic drug concentration triggers: A novel data‐driven approach to assess their value for medication safety surveillance in intensive care

British Journal of Clinical Pharmacology, EarlyView.
Aims Electronic triggers (e‐triggers) are used as screening signals to detect potential adverse drug events (ADEs) and offer an effective system level approach for medication safety surveillance. Their clinical utility is typically evaluated through time‐consuming manual chart review by experts, limiting implementation.
Anne Paulien Langermans, Izak A. R. Yasrebi‐de Kom, Dylan Wayne de Lange, Nicolette Fransisca de Keizer, Joanna E. Klopotowska, on behalf of the RESCUE Study group, C. S. C. Bouman, E. N. van Roon, P. F. Schutte, J. ten Cate, D. van Balen, S. Hendriks, C. Lau, W. J. Vermeijden, A. Beishuizen, J. B. Masselink, P. E. Spronk, H. J. M. van Kan, P. W. de Feiter, E. J. Wils, A. Wieringa, A. J. Valkenburg, W. M. van den Bergh, M. H. Renes, W. Bult, E. de Jonge, M. Hoeksema, E. J. Wesselink, I. M. Purmer, B. E. Bosma, S. H. W. van Bree, H. J. W. Lammers, R. J. Bosman, E. J. F. Franssen, A. Karakus, M. Sigtermans, E. M. Kuck, D. A. Dongelmans, M. J. H. Aries, E. V. Uijtendaal, M. C. Reuland   +40 more
wiley   +1 more source

Leveraging the accelerometer data for precise blood pressure assessment and management

Sensing and Bio-Sensing Research
In recent years, the use of accelerometer data in biosensors, which tracks physical activity levels and mobility, has gained more attention. Accelerometers offer enormous promise in the field of blood pressure measurement in addition to being utilized ...
Jipsa Chelora Veetil, Iyappan Gunasekaran, Zainab Riaz, Alireza Keramat   +3 more
doaj   +1 more source