Results 21 to 30 of about 2,571,762 (365)

Detection of Leptomeningeal Disease Using Cell-Free DNA From Cerebrospinal Fluid

JAMA Network Open, 2021
Key Points Question Can cell-free DNA analysis of cerebrospinal fluid provide additional diagnostic utility beyond cytologic assessment? Findings In this diagnostic study of 43 cerebrospinal fluid samples from 22 patients with leptomeningeal disease ...
Michael D. White, Robert H. Klein, Brian L. Shaw, Albert E Kim, Megha Subramanian, J. Mora, A. Giobbie-Hurder, Deepika Nagabhushan, Aarushi Jain, Mohini Singh, Benjamin M Kuter, Naema Nayyar, Mia S Bertalan, Jackson H Stocking, Samuel C. Markson, Matthew Lastrapes, C. Alvarez-Breckenridge, D. Cahill, G. Gydush, J. Rhoades, D. Rotem, V. Adalsteinsson, M. Mahar, Alexander Kaplan, K. Oh, R. Sullivan, E. Gerstner, S. Carter, P. Brastianos   +28 more
semanticscholar   +1 more source

Management of a human immunodeficiency virus case with discordant antiviral drug resistance profiles in cerebrospinal fluid compared with plasma: a case report

Journal of Medical Case Reports, 2022
Background Human immunodeficiency virus-1-associated neurocognitive disorder is a known complication in individuals treated with antiretroviral therapy.
Didi Bang, Jannik Fonager, Isik Somuncu Johansen   +2 more
doaj   +1 more source

Cerebrospinal fluid influx drives acute ischemic tissue swelling

Science, 2020
Spreading edema after stroke The brain is enveloped in a cushion of cerebrospinal fluid (CSF), which normally provides protection and helps to remove metabolic waste.
Humberto Mestre, Ting Du, Amanda M. Sweeney, Guojun Liu, A. Samson, Weiguo Peng, K. Mortensen, F. F. Stæger, P. Bork, Logan Bashford, Edna R. Toro, J. Tithof, D. H. Kelley, John H. Thomas, P. Hjorth, E. A. Martens, Rupal I. Mehta, O. Solis, P. Blinder, D. Kleinfeld, H. Hirase, Y. Mori, M. Nedergaard   +22 more
semanticscholar   +1 more source

Human CNS barrier-forming organoids with cerebrospinal fluid production

Science, 2020
Brain barrier and support in a dish Deep within the brain, the choroid plexus filters blood and secretes cerebrospinal fluid (CSF), a nutrient-rich liquid that bathes and supports the brain and protects it from entry of toxic compounds.
L. Pellegrini, Claudia Bonfio, Jessica Chadwick, Farida Begum, M. Skehel, Madeline A. Lancaster   +5 more
semanticscholar   +1 more source

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

Nature Communications, 2020
Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains superficial.
D. Schafflick, Chenling A. Xu, Maike Hartlehnert, Michael Cole, A. Schulte-Mecklenbeck, Tobias Lautwein, Jolien Wolbert, M. Heming, S. Meuth, T. Kuhlmann, C. Gross, H. Wiendl, N. Yosef, Gerd Meyer zu Horste   +13 more
semanticscholar   +1 more source

Neurofilament light as a biomarker of axonal degeneration in patients with mild cognitive impairment and Alzheimer’s disease

Journal of Integrative Neuroscience, 2021
Cerebrospinal fluid neurofilament light and plasma neurofilament light concentrations are elevated in patients with mild cognitive impairment and Alzheimer’s disease.
Yi Chen, Joseph Therriault, Jing Luo, Maowen Ba, Hua Zhang, Alzheimer’s Disease Neuroimaging Initiative   +5 more
doaj   +1 more source

Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke

Journal of Neurology Neurosurgery & Psychiatry, 2020
Background Emergence of the novel corona virus (severe acute respiratory syndrome (SARS)-CoV-2) in December 2019 has led to the COVID-19 pandemic. The extent of COVID-19 involvement in the central nervous system is not well established, and the presence ...
F. Al Saiegh, Ritam Ghosh, A. Leibold, M. Avery, R. Schmidt, Thana N. Theofanis, N. Mouchtouris, Lucas R. Philipp, S. Peiper, Zi-Xuan Wang, F. Rincon, S. Tjoumakaris, P. Jabbour, R. Rosenwasser, M. Gooch   +14 more
semanticscholar   +1 more source

Cerebrospinal fluid tracer efflux to parasagittal dura in humans

Nature Communications, 2020
The mechanisms behind molecular transport from cerebrospinal fluid to dural lymphatic vessels remain unknown. This study utilized magnetic resonance imaging along with cerebrospinal fluid tracer to visualize clearance pathways to human dural lymphatics ...
G. Ringstad, P. Eide
semanticscholar   +1 more source

Analysis of reasons impairing the quality of cerebrospinal fluid cell slide centrifugal sedimentation examination method and its preventive measures

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
It is well known that cerebrospinal fluid (CSF) cell slide centrifugal sedimentation examination method is a very important technique for the etiological diagnosis of many central nervous system (CNS) diseases, especially for infectious diseases ...
Xiu-chu SU
doaj   +1 more source

Choroid plexus and the blood–cerebrospinal fluid barrier in disease

Fluids and Barriers of the CNS, 2020
The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance.
P. Solár, Alemeh Zamani, L. Kubíčková, P. Dubový, M. Joukal   +4 more
semanticscholar   +1 more source