Results 121 to 130 of about 395,728 (365)

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

Nature Communications, 2020
Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in
S. Janelidze, E. Stomrud, Ruben Smith, S. Palmqvist, N. Mattsson, D. Airey, Nicholas K. Proctor, Xiyun Chai, S. Shcherbinin, J. Sims, G. Triana-Baltzer, C. Theunis, Randy Slemmon, M. Mercken, H. Kolb, J. Dage, O. Hansson   +16 more
semanticscholar   +1 more source

Association of Elevated Serum S100A8/A9 Levels and Cognitive Impairment in Systemic Lupus Erythematosus Patients

Arthritis Care &Research, Accepted Article.
Objectives Cognitive impairment (CI) is common in patients with Systemic Lupus Erythematosus (SLE). Despite its prevalence, the immune mechanisms are not well understood. We previously reported elevated serum levels of S100A8/A9 and MMP‐9 in SLE patients with CI.
Carolina Muñoz‐Grajales, Michelle L Barraclough, Juan P Diaz‐Martinez, Jiandong Su, Kathleen Bingham, Mahta Kakvan, Roberta Pozzi Kretzmann, Maria Carmela Tartaglia, Lesley Ruttan, May Y Choi, Simone Appenzeller, Sherief Marzouk, Dennisse Bonilla, Patricia Katz, Dorcas Beaton, Robin Green, Dafna D. Gladman, Joan Wither, Zahi Touma   +18 more
wiley   +1 more source

Human CNS barrier-forming organoids with cerebrospinal fluid production

Science, 2020
Brain barrier and support in a dish Deep within the brain, the choroid plexus filters blood and secretes cerebrospinal fluid (CSF), a nutrient-rich liquid that bathes and supports the brain and protects it from entry of toxic compounds.
L. Pellegrini, Claudia Bonfio, Jessica Chadwick, Farida Begum, M. Skehel, Madeline A. Lancaster   +5 more
semanticscholar   +1 more source

Computer simulation of syringomyelia in dogs [PDF]

, 2018
Syringomyelia is a pathological condition in which fluid-filled cavities (syringes) form and expand in the spinal cord. Syringomyelia is often linked with obstruction of the craniocervical junction and a Chiari malformation, which is similar in both ...
AC Freeman, AR Brodbelt, B Williams, B Williams, B Williams, BA Martin, BA Martin, BA Martin, C Rusbridge, C Rusbridge, C Rusbridge, C Rusbridge, C Rusbridge, CA Schneider, CD Bertram, CD Bertram, CD Bertram, CD Bertram, CJ Driver, Clare Rusbridge, DJ Marino, DN Levine, EC Clarke, F Loth, Holger A. Volk, HS Chang, IM Vavasour, J Strahle, JD Heiss, JE Parker, Jelena Jovanovik, K Berkouk, K Chandler, KH Stoverud, LE Bilston, LE Bilston, M Heil, M Kim, M Perdiki, MA Stoodley, MJ Hezzell, N Alperin, NJ Alperin, NJ Fischbein, NS Elliott, NS Elliott, NSJ Elliott, NSJ Elliott, PW Carpenter, R Fric, Robert Lloyd, S Cerda-Gonzalez, S Cirovic, S Cirovic, S Heidari Pahlavian, S Loderstedt, S Yildiz, SJ Hemley, SP Knowler, SP Knowler, Srdjan Cirovic, TH Milhorat, TH Milhorat, W Kalata, WD Whetstone   +64 more
core   +3 more sources

Fabrication of a Stable, Low‐Cost, Patient‐Specific, Brain Phantom with Ventricles for Ultrasound Imaging

Advanced Engineering Materials, EarlyView.
Patient‐specific brain phantoms can replace animal trials, aid presurgical training, and enable in silico disease research on cerebrospinal fluid and ventricles. This study presents a method to create ventricular brain phantoms from three‐dimensional magnetic resonance images brain scans, resulting in durable, tunable, reproducible models that mimic ...
Kajal Chandraprakash Jain, Ana Belen Amado Rey, Ana Carolina Gonçalves Seabra, Thomas Stieglitz   +3 more
wiley   +1 more source

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

Nature Communications, 2020
Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains superficial.
D. Schafflick, Chenling A. Xu, Maike Hartlehnert, Michael Cole, A. Schulte-Mecklenbeck, Tobias Lautwein, Jolien Wolbert, M. Heming, S. Meuth, T. Kuhlmann, C. Gross, H. Wiendl, N. Yosef, Gerd Meyer zu Horste   +13 more
semanticscholar   +1 more source

High Dynamic Range Thin‐Film Resistive Flow Sensors for Monitoring Diverse Biofluids

Advanced Functional Materials, EarlyView.
Thin‐film resistive flow sensors with thermoresistive and piezoresistive mechanisms are developed for biofluid monitoring. Fabricated using biocompatible materials and laser micromachining, the devices achieve sub‐millimeter dimensions and a broad dynamic range.
Latifah Almulla, Massimo Mariello, Christopher M Proctor   +2 more
wiley   +1 more source

Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke

Journal of Neurology Neurosurgery & Psychiatry, 2020
Background Emergence of the novel corona virus (severe acute respiratory syndrome (SARS)-CoV-2) in December 2019 has led to the COVID-19 pandemic. The extent of COVID-19 involvement in the central nervous system is not well established, and the presence ...
F. Al Saiegh, Ritam Ghosh, A. Leibold, M. Avery, R. Schmidt, Thana N. Theofanis, N. Mouchtouris, Lucas R. Philipp, S. Peiper, Zi-Xuan Wang, F. Rincon, S. Tjoumakaris, P. Jabbour, R. Rosenwasser, M. Gooch   +14 more
semanticscholar   +1 more source

Creutzfeldt-Jakob disease and homocysteine levels in plasma and cerebrospinal fluid [PDF]

, 2005
Background: There is evidence that homocysteine contributes to various neurodegenerative disorders. Objective: To assess the values of homocysteine in patients with Creutzfeldt-Jakob disease (CJD) in both cerebrospinal fluid (CSF) and plasma.
Bottiglieri T, Halliwell B, Hans A. Kretzschmar, Inga Zerr, Jens Wiltfang, Markus Otto, Otto M, Stefan Bleich, Stefan Kropp, Ubbink JB, Zerr I, Zerr I   +11 more
core   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source