Results 71 to 80 of about 253,674 (309)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

CSF Circulation and Congenital Hydrocephalus

Pediatric Neurology Briefs, 1997
A new model of the cerebrospinal fluid (CSF) circulation, involving brain capillaries as the main site of CSF absorption, is proposed from the Karolinska MR Research Center and Department of Neuroradiology, Karolinska Hospital, Stockholm, Sweden.
J Gordon Millichap
doaj   +1 more source

Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways

Communications Biology, 2022
To understand if brain interstitial fluid/cerebrospinal fluid (ISF/CSF) exchange, CSF turnover, blood-brain barrier function or proteolysis were affected by aging or the presence of β amyloid plaques, Elbert et al.
Donald L. Elbert, Bruce W. Patterson, Brendan P. Lucey, Tammie L. S. Benzinger, Randall J. Bateman   +4 more
doaj   +1 more source

Fibroblast growth factors 1 and 2 in cerebrospinal fluid are associated with HIV disease, methamphetamine use, and neurocognitive functioning. [PDF]

, 2016
BackgroundHuman immunodeficiency virus (HIV) and methamphetamine use commonly affect neurocognitive (NC) functioning. We evaluated the relationships between NC functioning and two fibroblast growth factors (FGFs) in volunteers who differed in HIV ...
Bharti, Ajay R, Cherner, Mariana, Ellis, Ronald J, Everall, Ian P, Grant, Igor, Heaton, Robert K, Letendre, Scott L, Masliah, Eliezer, Potter, Michael, Rosario, Debra, Woods, Steven Paul   +10 more
core   +2 more sources

Alcohol in Cerebrospinal Fluid (CSF) and Alcoholism

Human & Experimental Toxicology, 1992
Alcohol levels were measured in 15 cerebrospinal fluid (CSF) samples and 14 blood samples from grade III and IV male alcoholic patients with signs of nervous system involvement, and compared with levels detected in 11 CSF samples and 11 blood samples from abstemious patients or patients with grade I or II alcoholism whose CSF had been found to be ...
Agapejev, S., Vassilieff, I., Curi, P. R.   +2 more
openaire   +3 more sources

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis

Brazilian Journal of Infectious Diseases, 2019
The precise diagnosis of bacterial meningitis is essential. Cytological and biochemical examination of cerebrospinal fluid (CSF) are not specific.
Renan Barros Domingues, Márcio Vega dos Santos, Fernando Brunale Vilela de Moura Leite, Carlos Senne   +3 more
doaj   +1 more source

Circadian control of brain glymphatic and lymphatic fluid flow

Nature Communications, 2020
Glymphatic function is increased during the rest phase while more cerebrospinal fluid (CSF) drains directly to the lymphatic system during the active phase. The water channel aquaporin-4 supports these endogenous, circadian rhythms in CSF distribution.
Lauren M. Hablitz, Virginia Plá, Michael Giannetto, Hanna S. Vinitsky, Frederik Filip Stæger, Tanner Metcalfe, Rebecca Nguyen, Abdellatif Benrais, Maiken Nedergaard   +8 more
doaj   +1 more source

Optimum imaging and diagnosis of cerebrospinal fluid rhinorrhoea [PDF]

, 2000
Imaging is an important component in the investigation of unilateral watery rhinorrhoea suspicious of cerebrospinal fluid (CSF). Whilst the demonstration of the presence of beta 2 transferrin confirms that CSF is present it may prove difficult to ...
Howard, D, Lloyd, G, Lund, VJ, Savy, L
core   +1 more source