Results 101 to 110 of about 3,551,226 (289)

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Inflammatory changes in the choroid plexus following subarachnoid hemorrhage: the role of innate immune receptors and inflammatory molecules

Frontiers in Cellular Neuroscience
IntroductionThe choroid plexus is located in the cerebral ventricles. It consists of a stromal core and a single layer of cuboidal epithelial cells that forms the blood-cerebrospinal barrier.
Peter Solár, Peter Solár, Václav Brázda, Václav Brázda, Martin Bareš, Alemeh Zamani, Parisa EmamiAref, Andrea Joukal, Lucie Kubíčková, Erik Kročka, Klaudia Hašanová, Marek Joukal   +11 more
doaj   +1 more source

Fluid Distribution Pattern in Adult-Onset Congenital, Idiopathic, and Secondary Normal-Pressure Hydrocephalus: Implications for Clinical Care

Frontiers in Neurology, 2017
ObjectiveIn spite of growing evidence of idiopathic normal-pressure hydrocephalus (NPH), a viewpoint about clinical care for idiopathic NPH is still controversial.
Shigeki Yamada, Masatsune Ishikawa, Kazuo Yamamoto   +2 more
doaj   +1 more source

Mathematical modelling and analysis of cerebrospinal mechanics: an investigation into the parthogenesis of syringomyelia [PDF]

Syringomyelia is a disease in which fluid-filled cavities, called syrinxes, form in the spinal cord causing progressive loss of sensory and motor functions.
Elliott, Novak Samuel Jon
core  

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases [PDF]

, 2015
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in SLE. Although the mechanism of NPSLE remains unclear, cytokines and chemokines are considered to be involved in their pathogenesis.
Shin-ya Kawashiri, Nakashima, Yoshikazu, Kawakami, Atsushi, Kazuhiko Arima, Takahisa Suzuki, Iwamoto, Naoki, Hideki Nakamura, Ushigusa, Takeshi, Tamai, Mami, Nishino, Ayako, Tomoki Origuchi, Masakatsu Motomura, Yoshikazu Nakashima, Suzuki, Takahisa, Kawashiri, Shin-ya, Horai, Yoshiro, Arima, Kazuhiko, Motomura, Masakatsu, Mami Tamai, Takeshi Ushigusa, Origuchi, Tomoki, Hideki Nakajima, Nakamura, Hideki, Ayako Nishino, Yoshiro Horai, Atsushi Kawakami, Naoki Iwamoto, Nakajima, Hideki, Ichinose, Kunihiro, Kunihiro Ichinose   +29 more
core   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Compressão segmentar do plexo venoso extra-raquidiano: Valor para o diagnóstico de localização das afecções bloqueantes do canal raquidiano

Arquivos de Neuro-Psiquiatria, 1959
Outside and inside the vertebral canal, running along its entire length, there is a series of venous plexuses which anastomoses with each other and end in intravertebral veins.
Oswaldo Ricciardi Cruz
doaj   +1 more source

Expansion of neopterin and beta2-microglobulin in cerebrospinal fluid reaches maximum levels early and late in the course of human immunodeficiency virus infection [PDF]

, 1992
Inhaltsverzeichnis ...
Bogner, Johannes R., Matuschke, A., Junge-Hülsing, B., Kronawitter, Ursula, Sadri, Ifna, Goebel, Frank-Detlef   +5 more
core   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source