Animal stroke models and outcome evaluation: A review
Animal Models and Experimental Medicine, EarlyView.Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba +2 more
wiley +1 more source
Treadmill locomotion in the American alligator (Alligator mississippiensis) produces dynamic changes in intracranial cerebrospinal fluid pressure. [PDF]
Sci Rep, 2022 Young BA, Cramberg MJ.
europepmc +1 more source
Annals of Neurology, EarlyView.Objective Identification of cerebral amyloid angiopathy (CAA) before its hemorrhagic manifestations remains limited. We aimed to determine whether severe enlarged perivascular spaces in the centrum semiovale (EPVS‐CSO) identify a prehemorrhagic stage of sporadic CAA by predicting the first appearance of CAA‐related hemorrhagic lesions or incident ...
Baris Alten +8 more
wiley +1 more source
A Study of Cerebrospinal Fluid Pressure Measurement in Cats
, 1981 Program year: 1980-1981Digitized from print original stored in HDRHydrocephalus, a serious condition involving accumulation of excess cerebrospinal fluid in the ventricles of the brain and elevated cerebrospinal fluid pressure, can result from any of a ...
Pratt, Camellia Jane
core +1 more source
Cerebrospinal Fluid Pressure Dynamics as a Bedside Test in Traumatic Spinal Cord Injury to Assess Surgical Spinal Cord Decompression: Safety, Feasibility, and Proof-of-Concept. [PDF]
Neurorehabil Neural Repair, 2023 Kheram N +9 more
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.The nanoparticle consists of a 3 nm iron oxide core functionalized with an amphiphilic polymer coating containing Aβ‐targeting DSA moieties and biocompatible PEG chains. This design supports measurable transport in a BBB‐related model and specific interaction with Aβ species, while providing MRI contrast enhancement for diagnosis and therapeutic ...
Ao Shen +8 more
wiley +1 more source
Ventriculoperitoneal Shunt Drainage Increases With Gravity and Cerebrospinal Fluid Pressure Pulsations: Benchtop Model. [PDF]
Neurosurgery, 2021 Koueik J +9 more
europepmc +1 more source
Cerebrospinal Fluid Pressure Dynamics in Idiopathic Intracranial Hypertension
, 1992 Cerebrospinal fluid pressure dynamics were assessed in eight patients with pseudotumorcerebri, seven women and one man. Six were newly diagnosed and two had disease of several years duration.
Warren L. Felton III, MD; A. Marmarou, PhD
core
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source