Results 151 to 160 of about 113,579 (302)

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source

Altered Cerebrospinal Fluid Proteins in Smith-Lemli-Opitz Syndrome. [PDF]

J Proteome Res
Li W, Pergande MR, Serna-Perez F, Patel V, Crutchfield CA, Searle BC, Picache JA, Farhat NM, Wassif CA, Backlund PS, Bianconi S, Pacak K, Freel BA, Francis KR, Porter FD, Cologna SM.   +15 more
europepmc   +1 more source

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Cerebrospinal fluid proteins in meningitis [PDF]

, 1998
Ali, TAJBIBI Z, Ali, NASEEMA M, KHURSHIDt, M, WAQAR, MOHAMMAD A, Siddiqui, Anwar Ali   +4 more
core  

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Identification of gut microbiota causally associated with aging and longevity and mediation roles of the cerebrospinal fluid proteins: proteomic genetic evidence from Mendelian randomization. [PDF]

Geroscience
Liu R, Zhu Z, Zhu Y, Lin X, Li H, Wang T, Zheng J, Li M, Zhao Z, Xu Y, Lu J, Wang W, Ning G, Bi Y, Hu W, Xu M.   +15 more
europepmc   +1 more source

Reclaiming Anatomy as Method: From Morphological Reasoning to Clinical Relevance

Clinical Anatomy, EarlyView.
ABSTRACT In recent decades, molecular biology and omics technologies have profoundly reshaped biomedical research, with genomics, proteomics, and other high‐throughput approaches dominating scientific agendas and funding priorities. Within this molecular paradigm, however, the anatomical sciences face an epistemic and institutional tension: morphology,
Katia Cortese, Marco Frascio
wiley   +1 more source

Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection. [PDF]

PLoS Pathog
Hu Z, Cinque P, Dravid A, Hagberg L, Yilmaz A, Zetterberg H, Fuchs D, Gostner J, Blennow K, Spudich SS, Kincer L, Zhou S, Joseph SB, Swanstrom R, Price RW, Gisslén M.   +15 more
europepmc   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Neuroinflammation and glycosylation-related cerebrospinal fluid proteins for predicting functional decline in amyotrophic lateral sclerosis: a proteomic study. [PDF]

Front Neurol
Nakamura K, Fujita K, Suzuki M, Kunugi A, Hirozane Y, Kunikata T, Takahashi B, Narazaki G, Kondo H, Haji S, Hirai K, Izumi Y.   +11 more
europepmc   +1 more source