Results 51 to 60 of about 72,296 (243)

Novel solutions toward high accuracy automatic brain tissue classification in young children [PDF]

arXiv, 2020
Accurate automatic classification of major tissue classes and the cerebrospinal fluid in pediatric MR scans of early childhood brains remains a challenge. A poor and highly variable grey matter and white matter contrast on T1-weighted MR scans of developing brains complicates the automatic categorization of voxels into major tissue classes using state ...
arxiv  

MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, a rare neurologic disorder where a genetic mutation prevents dopamine production in the brain. Affected children fail to develop normal motor and cognitive functions.
Dalton H. Bermudez, Thomas Lilieholm, Walter F. Block   +2 more
wiley   +1 more source

Characterization of cerebrospinal fluid (CSF) microbiota from patients with CSF shunt infection and reinfection using high throughput sequencing of 16S ribosomal RNAgenes.

PLoS ONE, 2021
BackgroundNearly 20% of patients with cerebrospinal fluid (CSF) shunt infection develop reinfection. It is unclear whether reinfections are caused by an organism previously present or are independent infection events.ObjectiveWe used bacterial culture ...
Kathryn B Whitlock, Christopher E Pope, Paul Hodor, Lucas R Hoffman, David L Limbrick, Patrick J McDonald, Jason S Hauptman, Jeffrey G Ojemann, Tamara D Simon, Cerebrospinal FLuId MicroBiota in Shunts Study (CLIMB) Group   +9 more
doaj   +1 more source

Role of the Functional Gait Assessment in Validating Item Difficulty Hierarchy and Fall Risk for Idiopathic Normal Pressure Hydrocephalus

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Falls along with gait‐balance disturbances are important symptoms of idiopathic normal pressure hydrocephalus (iNPH). Objectives This study aimed to validate the Functional Gait Assessment (FGA) item‐difficulty hierarchy, determine its optimal fall cutoff value, and identify key items for assessing fall risk in iNPH.
Yasutaka Nikaido, Hideyuki Urakami, Naoya Ishida, Yohei Okada, Yuki Kawami, Takaki Inui, Masahiro Kameda, Yoshinaga Kajimoto, Ryuichi Saura   +8 more
wiley   +1 more source

MRI as a one-stop destination for evaluation of CSF shunt malfunction

The Egyptian Journal of Radiology and Nuclear Medicine, 2023
Background Despite the high-frequency rate of cerebrospinal fluid shunt malfunction, radiological evaluation of CSF shunts has remained deficient, focusing mainly on demonstrating secondary signs of shunt failure rather than evaluating the shunt tube ...
Eman Ahmed Hamed, Shaimaa Abdelsattar Mohammad, Shrouk M. Awadallah, Assem Mounir Metwalli Abdel-Latif, Abeer Maghawry Abd-Elhameed   +4 more
doaj   +1 more source

Anosmia and Upper Limb Rigidity—A Potential Phenotype of Idiopathic Normal Pressure Hydrocephalus with Cerebrospinal Fluid α‐Synuclein Seeds

Movement Disorders, EarlyView.
Abstract Background The pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) and its association with neurodegenerative disorders is poorly understood. Objectives The aim was to determine the prevalence of α‐synuclein pathology in iNPH and its associations with clinical characteristics. Methods We used α‐synuclein seed amplification assay
Sandrina Weber, Carly M. Farris, Yihua Ma, Mohammed Dakna, Maritta Starke, Sebastian Schade, Michael Bartl, Claudia Trenkwalder, Luis Concha‐Marambio, Brit Mollenhauer   +9 more
wiley   +1 more source

Characterization of cerebrospinal fluid (CSF) microbiota at the time of initial surgical intervention for children with hydrocephalus.

PLoS ONE, 2023
ObjectiveTo characterize the microbiota of the cerebrospinal fluid (CSF) from children with hydrocephalus at the time of initial surgical intervention.Study designCSF was obtained at initial surgical intervention.
Shailly Pandey, Kathryn B Whitlock, Matthew R Test, Paul Hodor, Christopher E Pope, David D Limbrick, Patrick J McDonald, Jason S Hauptman, Lucas R Hoffman, Tamara D Simon, Cerebrospinal FLuId MicroBiota in Shunts (CLIMB) Study Group   +10 more
doaj   +1 more source

Computer simulation of surgical interventions for the treatment of refractory pulmonary hypertension [PDF]

arXiv, 2021
This paper describes computer models of three interventions used for treating refractory pulmonary hypertension (RPH). These procedures create either an atrial septal defect, a ventricular septal defect, or, in the case of a Potts shunt, a patent ductus arteriosus.
arxiv  

Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next

Movement Disorders, EarlyView.
Abstract Knowledge of the genetic factors in normal pressure hydrocephalus (NPH) is rapidly evolving, with significant advances in recent years. We conducted a systematic review examining genetic contributions to NPH risk. Ovid Embase, Ovid Medline, Web of Science, and Cochrane Central were searched from inception through October 14, 2024, for human ...
Camila C. Piccinin, Saar Anis, Jeryl Ritzi T. Yu, Philippe A. Salles, Henry Mauricio Chaparro‐Solano, Avery Kundrick, Shelley Ivary, James Y. Liao, Sean J. Nagel, Ignacio F. Mata   +9 more
wiley   +1 more source

A comparison of two mathematical models of the cerebrospinal fluid dynamics [PDF]

arXiv, 2018
In this paper we provide the numerical simulations of two cerebrospinal fluid dynamics models by comparing our results with the real data available in literature. The models describe different processes in the cerebrospinal fluid dynamics: the cerebrospinal flow in the ventricles of the brain and the reabsorption of the fluid.
arxiv