Results 201 to 210 of about 58,328 (279)

Sunitinib as Second‐Line Treatment in Advanced Intrahepatic Cholangiocarcinoma: Results From the SUN‐CK GERCOR Phase II Trial

open access: yesLiver International, Volume 45, Issue 8, August 2025.
ABSTRACT Background & Aims Angiogenesis is critical in intrahepatic cholangiocarcinoma (ICC), a highly lethal cancer with limited treatment options. Sunitinib, a multi‐receptor tyrosine kinase inhibitor, has strong antiangiogenic and antitumor effects.
Louis Gros   +16 more
wiley   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, Volume 19, Issue 7, Page 2120-2132, July 2025.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Using the Orienting Hazard Prediction Test to Assess Fitness‐to‐Drive: Data From Stroke Survivors

open access: yesApplied Cognitive Psychology, Volume 39, Issue 4, July/August 2025.
ABSTRACT This study pioneers the exploration of the attentional orienting effect in experienced drivers: stroke survivors and healthy drivers. The Orienting Hazard Prediction Test (OHPT) consisted of 39 short videos shot in a naturalistic setting, including a target hazard situation just before the end of the video.
Cándida Castro   +8 more
wiley   +1 more source

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

open access: yesAdvanced Biology, Volume 9, Issue 7, July 2025.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang   +6 more
wiley   +1 more source

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