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Cerebrovascular Disorders: Role of Aging [PDF]
Therapeutic development for neurological diseases, whether cerebrovascular disease, vascular dementia, or Alzheimer's disease (AD), has been largely unsuccessful. Despite the apparent success of numerous pharmacologic agents in preclinical animal models, few have translated successfully from bench to bedside.
Buga, Ana-Maria+4 more
core +8 more sources
Cerebrovascular Disorders [PDF]
AbstractCerebrovascular disorders pose a global health concern. Advances in basic and clinical research, including induced pluripotent stem cell models and multi-omic approaches, have improved our understanding and management of these disorders. However, gaps in our knowledge remain.
Granata, Alessandra+2 more
openaire +5 more sources
Cerebrovascular Disorders Complicating Pregnancy [PDF]
This article discusses the physiologic changes of pregnancy and how they affect risk of ischemic and hemorrhagic stroke and then reviews epidemiology, diagnosis, and treatment of ischemic and hemorrhagic stroke in pregnancy and the puerperium.This article updates our understanding of the relationship of preeclampsia/eclampsia to the posterior ...
Steven K. Feske, Aneesh B. Singhal
europepmc +5 more sources
Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE) [PDF]
Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and ...
Abootalebi, S.+70 more
core +2 more sources
Emerging Therapies for Cerebrovascular Disorders [PDF]
New information about therapeutic interventions regarding several important aspects of cerebrovascular disease has appeared recently. This short review will focus on new therapeutic developments concerning the prevention of ischemic stroke, acute ischemic stroke therapy trials, and, lastly, the management of patients with intracranial aneurysms. Great
Antoni Davalos, Marc Fisher
openalex +8 more sources
Fractional Flow in Cerebrovascular Disorders [PDF]
There is an urgent need for stroke experts to advance the care of their patients, yet current approaches are outmoded and have not been successful. The traditional emphasis on the anatomical identification of disease, using percent luminal stenosis, results in suboptimal identification of lesions likely to produce recurrent ischemia and, consequently ...
Edward Feldmann, David S Liebeskind
openaire +4 more sources
Cerebrovascular Disorders of Childhood [PDF]
Ian J. Butler
openalex +4 more sources
Cerebrovascular disorders caused by hyperfibrinogenaemia [PDF]
Key points Hyperfibrinogenaemia (HFg) results in vascular remodelling, and fibrinogen (Fg) and amyloid β (Aβ) complex formation is a hallmark of Alzheimer's disease. However, the interconnection of these effects, their mechanisms and implications in cerebrovascular diseases are not known.
Nino Muradashvili+4 more
openalex +4 more sources
Deep-learning-enabled Brain Hemodynamic Mapping Using Resting-state fMRI [PDF]
Cerebrovascular disease is a leading cause of death globally. Prevention and early intervention are known to be the most effective forms of its management. Non-invasive imaging methods hold great promises for early stratification, but at present lack the sensitivity for personalized prognosis.
arxiv +1 more source
Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 [PDF]
Background and purpose Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported.
Boon, Paul+6 more
core +2 more sources