Results 111 to 120 of about 3,315,577 (358)

The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders

Toxins, 2018
Individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing cognitive disorders and dementia. Stroke is also highly prevalent in this population and is associated with a higher risk of neurological deterioration, in ...
Maryam Assem, Mathilde Lando, Maria Grissi, S. Kamel, Z. Massy, J. Chillon, L. Hénaut   +6 more
semanticscholar   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

CEREBROVASCULAR MORBIDITY, LETHALITY AND MORTALITY IN THE MOSCOW REGION IN 2014

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Cerebrovascular disorders are major contributors into mortality of the population. Annually, more than 14 000 subjects die of cardiovascular disorders in the Moscow Region, 50% of them when being in a hospital.Aim: Informational support of ...
A. N. Gurov, N. A. Katuntseva
doaj   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source

Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage

Frontiers in Neurology, 2019
Background: Small-artery occlusion (SAO) subtype accounts for a quarter of the cases of ischemic stroke and is mainly caused by pathological changes in cerebral small vessels, which also involve in deep intracerebral hemorrhage (dICH).
Zimo Chen, Zimo Chen, Zimo Chen, Zimo Chen, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jinglin Mo, Jie Xu, Jie Xu, Jie Xu, Jie Xu, Haiqiang Qin, Haiqiang Qin, Haiqiang Qin, Haiqiang Qin, Huaguang Zheng, Huaguang Zheng, Huaguang Zheng, Huaguang Zheng, Yuesong Pan, Yuesong Pan, Yuesong Pan, Yuesong Pan, Xia Meng, Xia Meng, Xia Meng, Xia Meng, Jing Jing, Jing Jing, Jing Jing, Jing Jing, Xianglong Xiang, Xianglong Xiang, Xianglong Xiang, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang   +38 more
doaj   +1 more source

Effect of Stress Hyperglycemia on Neurological Deficit and Mortality in the Acute Ischemic Stroke People With and Without Diabetes

Frontiers in Neurology, 2020
Objective: To determine the relationship between stress hyperglycemia and prognosis of acute ischemic stroke people with and without diabetes.Methods: A subgroup of 8,622 acute ischemic stroke people with baseline levels of fasting blood glucose and ...
Jiejie Li, Jiejie Li, Jiejie Li, Jiejie Li, Kehua Quan, Kehua Quan, Kehua Quan, Kehua Quan, Yilong Wang, Yilong Wang, Yilong Wang, Yilong Wang, Xingquan Zhao, Xingquan Zhao, Xingquan Zhao, Xingquan Zhao, Zixiao Li, Zixiao Li, Zixiao Li, Zixiao Li, Yuesong Pan, Yuesong Pan, Yuesong Pan, Yuesong Pan, Hao Li, Hao Li, Hao Li, Hao Li, Liping Liu, Liping Liu, Liping Liu, Liping Liu, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang   +35 more
doaj   +1 more source

Vinpocetine and Pyritinol: A New Model for Blood Rheological Modulation in Cerebrovascular Disorders—A Randomized Controlled Clinical Study

BioMed Research International, 2014
Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors.
Hayder M. Alkuraishy, A. Al-Gareeb, Ali K. Albuhadilly   +2 more
semanticscholar   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

Iron Deficiency Anemia: An Unexpected Cause of an Acute Occipital Lobe Stroke in an Otherwise Healthy Young Woman [PDF]

, 2020
A 29-year-old caucasian woman who presented to the hospital with an acute onset of right eye visual disturbance and headache was found to have an acute left occipital lobe infarction.
Nace, Travis C, O\u27Sullivan, Conor, Shan, Khine S, Zhang, Qian   +3 more
core   +1 more source

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis [PDF]

, 2016
Objective: First-degree atrioventricular block is frequently encountered in clinical practice and is generally considered a benign process. However, there is emerging evidence that prolonged PR interval may be associated with adverse outcomes. This study
Barker, Diane, Beynon, Rhys, Buchan, Iain, Kwok, Chun Shing, Loke, Yoon K, Mamas, Mamas A, Morley-Davies, Adrian, Myint, Phyo K, Nolan, James, Patwala, Ashish, Rashid, Muhammad, Satchithananda, Duwarakan   +11 more
core   +1 more source