Results 111 to 120 of about 331,793 (319)

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

Advanced Science, EarlyView.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang, Zhishen Cai, Xingfeng Mao, Yixuan Zhang, Yunlong Pan, Jiawen Cheng, Xuechun Wang, Hengyi Song, Sasaki Takuya, Ming Lu, Gang Hu, Xiuxiu Liu, Yingmei Lu, Feng Han   +13 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Platelet Count Predicts Adverse Clinical Outcomes After Ischemic Stroke or TIA: Subgroup Analysis of CNSR II

Frontiers in Neurology, 2019
Background: The clinical significance of platelet count (PC) for ischemic cerebrovascular disease is not well-established and further risk stratification according to baseline PC within normal range has not been reported before.
Ming Yang, Ming Yang, Ming Yang, Ming Yang, Yuesong Pan, Yuesong Pan, Yuesong Pan, Yuesong Pan, Zixiao Li, Zixiao Li, Zixiao Li, Zixiao Li, Hongyi Yan, Hongyi Yan, Hongyi Yan, Hongyi Yan, Xingquan Zhao, Xingquan Zhao, Xingquan Zhao, Xingquan Zhao, Liping Liu, Liping Liu, Liping Liu, Liping Liu, Jing Jing, Jing Jing, Jing Jing, Jing Jing, Xia Meng, Xia Meng, Xia Meng, Xia Meng, Yilong Wang, Yilong Wang, Yilong Wang, Yilong Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang, Yongjun Wang   +39 more
doaj   +1 more source

Cerebrovascular Regulation in Neurological Disorders

BioMed Research International, 2018
Cerebrovascular regulation, referring to cerebral autoregulation, cerebrovascular reactivity, and neurovascular coupling, are intrinsic control mechanism of cerebral blood flow, and considered critical for the maintenance of adequate cerebral perfusion. Much previous work has related cerebrovascular regulation to the occurrence and prognosis of a range
Yi Yang, David Simpson, Bingren Hu, Jia Liu, Li Xiong   +4 more
openaire   +4 more sources

Context-based task ontologies for clinical guidelines [PDF]

, 2004
Evidence-based medicine relies on the execution of clinical practice guidelines and protocols. A great deal of of effort has been invested in the development of various tools which automate the representation and execution of the recommendations ...
Ciccarese, Paolo, Kumar, Anand, Piazza, Matteo, Smith, Barry   +3 more
core  

A Hybrid Diffusion Model Enhances Multiparametric 3D Photoacoustic Computed Tomography

Advanced Science, EarlyView.
The hybrid diffusion PACT (HD‐PACT) system enhances dynamic multiparametric information using only 128–256 ultrasound elements. By overcoming limited‐view artifacts, HD‐PACT refines structural and functional information such as oxygen saturation observed in 3D premium PACT with > 1000 elements. Through cost‐effective and faster multiparametric imaging,
Hyunsu Jeong, Seunghun Oh, Seongwook Choi, Jiwoong Kim, Jinge Yang, Chulhong Kim   +5 more
wiley   +1 more source

Comparative analysis of cognitive functions in patients with episodic and chronic tension-type headache combined with psychovegetative syndrome and cerebrovascular disorders

Бюллетень сибирской медицины, 2008
The purpose of the study was to compare cognitive functions in patients with episodic tension-type headache (EpTTH) and chronic tension-type headache (ChTTH).EpTTH was diagnosed in 34 patients in which it combined with psychovegetative syndrome in 17 ...
Ye. A. Yegorova, V. N. Grigoriyeva
doaj   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

Advanced Science, EarlyView.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao, Cui Zhang, Hehua Lei, Weichuan Lin, Wenkai Yu, Xin Gao, Yanmeng He, Xinzhi Li, Qingwei Xiang, Zhiwen Zhang, Weifei Luo, Andrew D. Patterson, Limin Zhang, Gang Chen   +13 more
wiley   +1 more source