Results 131 to 140 of about 3,152,690 (357)
Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives
Chemistry &Biodiversity, EarlyView.ABSTRACT Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, predicted the ...
Michele Goulart dos Santos +8 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract Alzheimer's disease (AD), characterized by β‐amyloid (Aβ) plaques and neurofibrillary tangles, is the leading cause of dementia globally. Donanemab is a humanized immunoglobulin G1 in development as a treatment to slow AD progression. This study aimed to evaluate the safety, tolerability, pharmacokinetics (PKs), and immunogenicity of donanemab
Junyu Xu +5 more
wiley +1 more source
Iron Deficiency Anemia: An Unexpected Cause of an Acute Occipital Lobe Stroke in an Otherwise Healthy Young Woman [PDF]
, 2020 A 29-year-old caucasian woman who presented to the hospital with an acute onset of right eye visual disturbance and headache was found to have an acute left occipital lobe infarction.
Nace, Travis C +3 more
core +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract Centanafadine is a norepinephrine/dopamine/serotonin reuptake inhibitor in development for treatment of attention‐deficit/hyperactivity disorder. This double‐blind, placebo‐ and moxifloxacin‐controlled, 3‐period crossover trial evaluated the effects of centanafadine (EB‐1020) and its metabolite (EB‐10601) on cardiac repolarization in 30 ...
Osman S. Turkoglu +3 more
wiley +1 more source
Movement Disorders Following Cerebrovascular Lesions in Cerebellar Circuits
Journal of Movement Disorders, 2016 Cerebellar circuitry is important to controlling and modifying motor activity. It conducts the coordination and correction of errors in muscle contractions during active movements.
Seong-Min Choi
semanticscholar +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi +6 more
wiley +1 more source
Editorial: New Advances in Cerebrovascular Disorders. [PDF]
J Clin Med, 2023 Karapanayiotides T, Krogias C.
europepmc +1 more source
Movement Disorders Following Cerebrovascular Lesion in the Basal Ganglia Circuit
Journal of Movement Disorders, 2016 Movement disorders are primarily associated with the basal ganglia and the thalamus; therefore, movement disorders are more frequently manifest after stroke compared with neurological injuries associated with other structures of the brain.
Jinse Park
semanticscholar +1 more source
Widespread Skin Telangiectasias in Spinocerebellar Ataxia Type 27B
Annals of Neurology, EarlyView.
Victor Alm +3 more
wiley +1 more source