Results 251 to 260 of about 331,793 (319)

A Novel α‐Synuclein K58N Missense Variant in a Patient with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α‐synuclein (aSyn), are linked to rare familial forms of PD. Objective Our goal was to assess the clinical presentation and the biological effects of a novel K58N ...
Mohammed Al‐Azzani, Sandrina Weber, Nagendran Ramalingam, Maria Ramón, Liana Shvachiy, Gonçalo Mestre, Michael Zech, Kevin Sicking, Alain Ibáñez de Opakua, Vidyashree Jayanthi, Leslie Amaral, Aishwarya Agarwal, Aswathy Chandran, Susana R. Chaves, Juliane Winkelmann, Claudia Trenkwalder, Maike Schwager, Silke Pauli, Ulf Dettmer, Claudio O. Fernández, Janin Lautenschläger, Markus Zweckstetter, Ruben Fernandez‐Busnadiego, Brit Mollenhauer, Tiago Fleming Outeiro   +24 more
wiley   +1 more source

A New Phenotype–Genotype Correlation for FIG4 and Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Iro Boura, Panayiotis Mitsias, Sofia Erimaki, Efrosini Papadaki, Cleanthe Spanaki   +4 more
wiley   +1 more source

AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression

Movement Disorders, EarlyView.
Abstract Objectives The aim was to evaluate the safety, tolerability, pharmacokinetics, and potential clinical efficacy of AZP2006, an oral pleiotropic drug modulating progranulin levels, in patients with progressive supranuclear palsy (PSP), a rare tauopathy. Methods A randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted at
Jean‐Christophe Corvol, Mickael Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel, David Devos, Sara Sambin, Nicolas Carrière, Günter Höglinger, Marie Lebouteux, Graziella Mangone, Noelle Callizot, Aurélien Blondel, Olivier Defert, Cecilia Estrella, Artin Karapet, Philippe Verwaerde, Luc Defebvre   +17 more
wiley   +1 more source

Rehabilitation of Attentional Disorders in Cerebrovascular Disease.

, 1998
Hajime Hirabayashi, Koichiro Inaki, Junko Hirabayashi, Toshio Kanai, Makoto Izawa, Hidehiko Ichikawa   +5 more
openalex   +2 more sources

RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications

Movement Disorders, EarlyView.
Abstract Background Primary brain calcifications are observed in several inherited diseases due to different pathogenic mechanisms, including the disruption of the neurovascular unit, mitochondrial dysfunction, and impaired nucleic acid metabolism.
Edoardo Monfrini, Paola Rinchetti, Mathieu Anheim, Anna Klingseisen, Ouhaid Lagha‐Boukbiza, Zhidong Cen, Dehao Yang, Xinhui Chen, Reza Maroofian, Henry Houlden, Gioia Cappelletti, Anne‐Claire Richard, Olivier Quenez, Camilo Toro, Steven J. Frucht, Francesco Lotti, Wei Luo, David Hunt, Gael Nicolas, Giulietta M. Riboldi   +19 more
wiley   +1 more source

Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders

, 2012
Axel Montagne, Maxime Gauberti, Richard Macrez, Amandine Jullienne, Aurélien Briens, J. Raynaud, Gaëlle Louin, Alain Buisson, Benoît Haelewyn, Fabián Docagne, Gilles Defer, Denis Vivien, Eric Maubert   +12 more
openalex   +2 more sources

Longitudinal Blood‐Biomarker‐Based Assessment of Brain Injury in Patients Undergoing Deep Brain Stimulation and Magnetic Resonance–Guided Focused Ultrasound

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) and magnetic resonance–guided focused ultrasound (MRgFUS) are associated with neuroaxonal damage and astroglial activation; yet their extent and timing remain unclear despite clinical relevance for monitoring and outcome assessment.
Justina Dargvainiene, Ann‐Kristin Helmers, Juliana Naumann, Carl Alexander Gless, Bettina Möller, Julius Welzel, Frank Leypoldt, Johannes Hensler, Ina Tesseur, Klaus‐Peter Wandinger, Günther Deuschl, Daniela Berg, Steffen Paschen   +12 more
wiley   +1 more source

Cerebrovascular insult as a consequence of poor health behaviour in patients with schizophrenia and bipolar disorder

M. Arnautovic Tahirovic, Muhamed Zuko, I. Lokmic Pekic, Nejra Siručić, A. Tahirovic   +4 more
openalex   +1 more source

HEADACHE, SEIZURES, COGNITIVE DISORDERS, AND CEREBROVASCULAR DISEASES AS THE MOST COMMON NEUROPSYCHIC SYNDROMES IN SYSTEMIC LUPUS ERYTHEMATOSUS

, 2014
Н. В. Пизова
openalex   +1 more source

ASL 4D MRA Intracranial Vessel Segmentation With Deep Learning U‐Nets

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To propose a spatio‐temporal U‐Net based network (4DST) that exploits both spatial and dynamic information while avoiding memory‐intensive 4D convolutional layers for ASL‐based non‐contrast enhanced 4‐dimensional MR angiography (4D MRA) vessel segmentation.
Sang Hun Chung, Zihan Wang, Tianrui Zhao, Zhitao Li, Chase S. Krumpelman, Sarah J. Moum, Sameer A. Ansari, Lirong Yan   +7 more
wiley   +1 more source