Results 221 to 230 of about 691,372 (295)

Dose-Response Efficacy and Safety of Factor XI/XIa Inhibitors in Atrial Fibrillation; a Systematic Review and Meta-Analysis With Subgroup Exploration and Trial Sequential Validation. [PDF]

Clin Cardiol
Faizan MA, Rehman T, Dandamudi M, Menon JA, Ferrara VZ, Kholeif Z, Tanvir A, Saeed F, Ikram J, Chaudhri M, Espiche C, Aslam MMS, Humayun Z, Khalid AM, Waqas SA, Ahmad R, Cerna L.   +16 more
europepmc   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Prognostic factors for pain intensity and function in individuals with temporomandibular disorders (TMDs): a systematic review and meta-analysis. [PDF]

BMJ Open
Amaral M, Fukusawa L, Lourenço BM, Campos MGM, El-Hage Y, Oliveira VC, Galace de Freitas D.   +6 more
europepmc   +1 more source

Uncertainty Calibration in Molecular Machine Learning: Comparing Evidential and Ensemble Approaches

Chemistry – A European Journal, EarlyView.
Raw uncertainty estimates from deep evidential regression and deep ensembles are systematically miscalibrated. Post hoc calibration aligns predicted uncertainty with true errors, improving reliability and enabling efficient active learning and reducing computational cost while preserving predictive accuracy.
Bidhan Chandra Garain, Max Pinheiro Jr., Matheus de Oliveira Bispo, Mario Barbatti   +3 more
wiley   +1 more source

Soluble urokinase plasminogen activator receptor and perioperative complications: a systematic review. [PDF]

BMC Anesthesiol
Gungor AB, Pennathur P, Guran HS, Chu W, Roshanov PS.   +4 more
europepmc   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Electroacupuncture for the prevention of perioperative neurocognitive disorder in elderly patients undergoing general anesthesia: a systematic review and meta-analysis. [PDF]

Front Med (Lausanne)
Wu C, Wei X, Luo F, Li J, Kwan YYJ, Wang K, Zhou J.   +6 more
europepmc   +1 more source

Patient‐ and Clinician‐Related Factors Associated With the Reduction in Opioid Use Among Adults With Chronic Non‐Cancer Pain: A Systematic Review

Clinical Pharmacology &Therapeutics, EarlyView.
Despite known risks, opioids are widely used for chronic non‐cancer pain (CNCP). Clinical guidelines now recommend deprescribing, but factors predicting success are poorly understood. This systematic review aimed to identify clinician and patient factors associated with attaining successful opioid dose reduction or discontinuation in adults with CNCP ...
Alessandra C. Marcelo, Sarah N. Hilmer, David J. Hunter, Stephanie Mathieson, Riyaas Mohamed, Leo Li, Natalie Fung, Anthony Yue, Manuela L. Ferreira   +8 more
wiley   +1 more source

Antibiotic Prophylaxis Strategies and Surgical Site Infections in Colorectal Surgery: A Systematic Review and Network Meta-Analysis.

JAMA Netw Open
Motaghi S, Karam SG, Mulazzani F, Mirzayeh Fashami F, Buchan TA, Ibrahim S, Moradi Falah Langeroodi S, Khademioore S, Couban RJ, Mbuagbaw L, Mertz D, Loeb M.   +11 more
europepmc   +1 more source

Effect of root canal filling techniques and materials on endodontic treatment outcomes: a systematic review and meta-analysis. [PDF]

Sci Rep
Mushtaq A, Alsanafi S, Elmsmari F, González JA, Garcia-Font M, Abella Sans F, Afrashtehfar KI, Abbott PV.   +7 more
europepmc   +1 more source