Results 231 to 240 of about 1,105,161 (348)

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang   +15 more
wiley   +1 more source

National Board Certificates

open access: bronze, 1926
FRED C. ZAPFFE
openalex   +1 more source

Abnormal β‐Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin   +6 more
wiley   +1 more source

Boosts in Polarization and Piezoelectric Responses of Lead‐Free Ferroelectrics through Strain‐Enhanced Glassy Coexistent Polars with High Dynamics

open access: yesAdvanced Science, EarlyView.
An effective strategy by constructing strain‐enhanced glassy coexistent polars near ferroelectric tricritical point to simultaneously improve polarization response and reduce energy loss is uncovered in (Ba0.84Ca0.16)0.985Bi0.01(Ti0.9Zr0.07Sn0.03)1‐x/100Hfx/100O3 (xHf) system and verified by phase‐field simulations with supporting high resolution ...
Liqiang He   +11 more
wiley   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

open access: yesAdvanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves   +17 more
wiley   +1 more source

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