Results 231 to 240 of about 1,105,161 (348)
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang+15 more
wiley +1 more source
Impact of Missing Values in the Self-Administered Washington Group Short Set: A Cross-Sectional Study Using Secondary Data of a National Survey of Persons With Disabilities in Japan. [PDF]
Saito T, Imahashi K.
europepmc +1 more source
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin+6 more
wiley +1 more source
An effective strategy by constructing strain‐enhanced glassy coexistent polars near ferroelectric tricritical point to simultaneously improve polarization response and reduce energy loss is uncovered in (Ba0.84Ca0.16)0.985Bi0.01(Ti0.9Zr0.07Sn0.03)1‐x/100Hfx/100O3 (xHf) system and verified by phase‐field simulations with supporting high resolution ...
Liqiang He+11 more
wiley +1 more source
Standards in sync: five principles to achieve semantic interoperability for TRUE research for healthcare. [PDF]
Facile R+3 more
europepmc +1 more source
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves+17 more
wiley +1 more source
Educational inequalities in dementia-related mortality using a multiple cause of death approach and their contribution to life expectancy differences in Spain. [PDF]
Spijker JJA+4 more
europepmc +1 more source