Results 41 to 50 of about 1,134,207 (301)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Osmanlı’dan Erken Cumhuriyet Dönemine Miras Kalan Bir İlköğretim Meselesi; Muallim Muavinleri

Turkish History Education Journal, 2020
19. yüzyılda dağılma sürecine giren Osmanlı Devleti kötü gidişi engellemek adına ıslahatlar yapmaya başlamıştır. Bu bağlamda yapılan ıslahatlar arasında eğitim alanında yapılanlar oldukça dikkat çekicidir.
Ayse Yanardağ
doaj   +1 more source

Quantum Certificate Complexity [PDF]

, 2002
Given a Boolean function f, we study two natural generalizations of the certificate complexity C(f): the randomized certificate complexity RC(f) and the quantum certificate complexity QC(f). Using Ambainis' adversary method, we exactly characterize QC(f)
Aaronson, Scott
core   +6 more sources

Towards the Integration of an Intuitionistic First-Order Prover into Coq

, 2016
An efficient intuitionistic first-order prover integrated into Coq is useful to replay proofs found by external automated theorem provers. We propose a two-phase approach: An intuitionistic prover generates a certificate based on the matrix ...
Kunze, Fabian
core   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

X.509 certificate error testing [PDF]

, 2018
X.509 Certificates are used by a wide range of technologies to verify identities, while the SSL protocol is used to provide a secure encrypted tunnel through which data can be sent over a public network.
Jimenez M., Momani E. M. H., Toma C
core   +2 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Utility of advanced training skills among GPs: a systematic review

Rural and Remote Health
Introduction: Advanced Skills Training (AST) is designed to provide GPs with an opportunity to enhance their clinical practice in a narrower speciality.
Hannah Mason, Abdul-Aziz Seidu , Francis Albert, Emma Anderson, Faith Alele, Lawrie McArthur, Aaron Hollins, Paula Heggarty, Tarun Sen Gupta, Richard Hays, Bunmi Malau-Aduli   +10 more
doaj   +1 more source

The Rise of Certificate Transparency and Its Implications on the Internet Ecosystem

, 2018
In this paper, we analyze the evolution of Certificate Transparency (CT) over time and explore the implications of exposing certificate DNS names from the perspective of security and privacy.
Amann, Johanna, Brent, Lexi, Carle, Georg, Gasser, Oliver, Holz, Ralph, Nolte, Theodor, Scheitle, Quirin, Schmidt, Thomas C., Wählisch, Matthias   +8 more
core   +1 more source