Results 41 to 50 of about 1,105,161 (348)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Hábitos de estudio y aprendizaje autorregulado en estudiantes universitarios
Revista Educa UMCH, 2021 La presente investigación tuvo como objetivo general determinar si existe relación entre las variables hábitos de estudio y aprendizaje autorregulado. El diseño de estudio fue no experimental transversal de alcance correlacional.
Sandra Gabriela Terry Advíncula +1 more
doaj +1 more source
On the Power of Non-Adaptive Learning Graphs
, 2012 We introduce a notion of the quantum query complexity of a certificate structure. This is a formalisation of a well-known observation that many quantum query algorithms only require the knowledge of the disposition of possible certificates in the input ...
Belovs, Aleksandrs, Rosmanis, Ansis
core +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Four Certificates of Holy Orders Taken by Clerics from the Krakow Diocese
Folia Historica Cracoviensia, 2018 There are few records showing the practice of the holy orders taken by local clergy in medieval Krakow diocese. With the exception of two short lists of acolytes ordained by bishop Jan Rzeszowski, we do not have any name lists of clergymen ordained by ...
Krzysztof Kaczmarek
doaj +1 more source
Quantum Certificate Complexity [PDF]
, 2002 Given a Boolean function f, we study two natural generalizations of the certificate complexity C(f): the randomized certificate complexity RC(f) and the quantum certificate complexity QC(f). Using Ambainis' adversary method, we exactly characterize QC(f)
Aaronson, Scott
core +6 more sources
Towards the Integration of an Intuitionistic First-Order Prover into Coq
, 2016 An efficient intuitionistic first-order prover integrated into Coq is useful to replay proofs found by external automated theorem provers. We propose a two-phase approach: An intuitionistic prover generates a certificate based on the matrix ...
Kunze, Fabian
core +2 more sources
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Osmanlı’dan Erken Cumhuriyet Dönemine Miras Kalan Bir İlköğretim Meselesi; Muallim Muavinleri
Turkish History Education Journal, 2020 19. yüzyılda dağılma sürecine giren Osmanlı Devleti kötü gidişi engellemek adına ıslahatlar yapmaya başlamıştır. Bu bağlamda yapılan ıslahatlar arasında eğitim alanında yapılanlar oldukça dikkat çekicidir.
Ayse Yanardağ
doaj +1 more source