Results 131 to 140 of about 322,522 (351)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Incomplete Regulations of Mediator Competence Standards As A Requirement For Members of Consumer Dispute Resolution Agencies

Yurisdiksi: Jurnal Wacana Hukum dan Sains
This thesis examines the incompleteness of the mediator competency standards set in the Minister of Trade Regulation No. 72 of 2020 as a requirement for members of the Consumer Dispute Resolution Agency (BPSK).
Rayhan Rizky Fitrianto, Hamidi Masykur, Yenny Eta Widyanti   +2 more
doaj   +1 more source

A Call to Reconsider Certification Authority Authorization (CAA)

9 pages, 4 ...
Tehrani, Pouyan Fotouhi, Hiesgen, Raphael, Schmidt, Thomas C., Wählisch, Matthias   +3 more
openaire   +2 more sources

Blockchain and certificate authority cryptography for an asynchronous on-line public notary system

, 2018
Abelardo Arredondo
openalex   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Optimized Fuzzy based Malicious Node Detection on Routing and Certificate Authority based Secure Communication in Wireless Ad-HOC Network

, 2019
K. Rajkumar, M. K. Jeyakumar, I Chlamtac, M Conti, Jjn Liu, C Perkins, J Cho, A Swami, I Chen, F Azzedin, A Ridha, A Rizvi, C Perkins, E Royer, P Basu, N Khan, Tdc Little, Lee Suw, Gerlam Sj, X Li, Z Jia, P Zhang, R Zhang, H Wang, C Chiang, H Wu, W Liu, M Gerla, K Kumar, V Singh, N Haddadou, A Rachedi, Y Ghamri-Doudane, M Rafsanjani, H Fatemidokht, P Vijayakumar, M Azees, A Kannan, Jegatha Deborah, L, C Saloua, C Salim, R Logambigai, A Kannan, A Ghaffari, S Ahmed, S Al-Rubeaai, K Tepe, S Muthurajkumar, S Ganapathy, M Vijayalakshmi, A Kannan, D Hai, Le Vinh, T, S Marti, T Giuli, K Lai, M Baker, P Pappadimitratos, Z Haas, K Govindan, P Mohapatra, J Esch, M Momani, S Challa, K Ramana, A Chari, N Kasiviswanth, Guizani Khokhar, M, Meg Moe, B Helvik, S Knapskog, J Luo, X Liu, Fan, K Kulothungan, Angel Arul Jothi, J Kannan, A, J Ren, Y Zhang, K Zhang, X Shen, J Ren, Y Zhang, K Zhang, X Shen, J Ren, Y Zhang, K Zhang, X Shen, F Bao, R Chen, M Chang, J Cho, R Li, J Li, P Liu   +99 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Measuring Brief (EPA) [PDF]

, 2018
Govindgari, Shravya, Jones, Zachary, Subramanian, Narayan   +2 more
core   +2 more sources