Results 121 to 130 of about 1,557,605 (255)
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
TRACEABILITY AND CERTIFICATION IN MEAT SUPPLY CHAINS [PDF]
Food safety problems such as the BSE and dioxin crises focused attention on traceability systems and the certification of such systems. This study analyzes the status and perspectives of traceability systems and certification schemes, and reviews their ...
Meuwissen, Miranda P.M. +3 more
core
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
The Role of Land Certification in Reducing Gender Gaps in Productivity in Rural Ethiopia [PDF]
The importance of providing secure land rights to smallholder farmers in developing countries is now widely recognized. In line with this, our paper analyzes the impact of land certification on boosting productivity of female-headed households in ...
Bezabih, Mintewab, Holden, Stein
core
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Initial Teacher Certification Testing: Preservice Teachers’ Experiences and Perceptions
Canadian Journal of Education, 2002 The introduction of an initial teacher certification test in Ontario in 2002 was met by a wide range of responses from preservice teachers. This study, based on an April 2002 survey of 535 preservice teachers in a large initial teacher education program,
Ruth Childs, Maura Ross, Andrew Jaciw
doaj +2 more sources
Evaluation of the NIOSH certification program Division of Safety Research Testing and Certification Branch [PDF]
"Regulation, technical reports, and program strategies of the NIOSH testing and Certification Branch (TCB) programs for the evaluation and certification of personal protective equipment (PPE) and hazard measuring instruments (HMI) were analyzed by ...
core +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley +1 more source
Variation in Organic Standards Prior to the National Organic Program [PDF]
Interest in establishing nationally uniform certification, labeling, and management standards for organic products grew out of concern that the existence of multiple standards led to consumer and supply chain confusion about, and lack of confidence in ...
Fetter, T. Robert, Caswell, Julie A.
core
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source