Results 121 to 130 of about 563,065 (308)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Sustainable agriculture made easy: CETARA-NF's self-certification

Journal of Agriculture and Food Research
Consumers can receive guarantees through the certified evaluation tool of agriculture resources analysis of natural farming (CETARA NF) without having to deal with costly third-party certification's entry obstacles or complex participatory guarantee ...
Rohit Kumar Vashishat, Subhash Sharma, Rajeshwar Singh Chandel, Inder Dev, Gaurav Singh Chauhan, Divyanshu, Ashish Gupta, Manoj Gupta, Chinglembi Laishram   +8 more
doaj   +1 more source

Airworthiness considerations [PDF]

Guidance is provided for the airworthiness approval of both annunciation only and annunciation with guidance airborne windshear warning systems. Characteristics of a comprehensive certification plan, the criticality of certain system failure cases for ...
Stoer, Ray
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

What Triggers Environmental Management and Innovation? – Empirical Evidence for Germany [PDF]

It is frequently hypothesized that environmental management systems (EMSs) may improve a firm’s environmental performance. Whether or not this hypothesis is true is as important from the perspective of environmental policy as questions relating to the ...
Jens Horbach, Klaus Rennings, Manuel Frondel   +2 more
core  

Factors influencing the perception of organic certification logos in Turkey [PDF]

, 2013
Consumers’ perceptions on organic certification logos and the factors influencing these perceptions were explored. Data from surveys conducted in major cities of Turkey revealed that organic food consumers had little knowledge about logos, although the
Abay, C., Boyaci, M., Hamm, U., Janssen, M., Karahan Uysal, Ö., Miran, B.   +5 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Low-Carbon Certification Systems in Agriculture: A Review

Applied Sciences
The use of certification systems in agriculture mitigates greenhouse gas (GHG) emissions and promotes sustainable low-carbon practices. Their implementation contributes to the rational use of resources and results in the development of a human-centric ...
Georgios Bartzas, Maria Doula, Konstantinos Komnitsas   +2 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source