Results 131 to 140 of about 563,065 (308)

A SysML-based framework towards EASA CS-23 digitalization: An MBSE approach

open access: yesTransportation Research Interdisciplinary Perspectives
The general aviation sector is undergoing rapid transformation, driven by technological innovation and increasing market demand. However, certification frameworks remain predominantly document-based, resulting in inefficiencies and elevated costs.
Pierluigi Della Vecchia   +6 more
doaj   +1 more source

An Overview of Supplier Rating, Certification and Selection Systems in the Defense Aircraft Industry [PDF]

open access: yes, 1995
In this paper, we report on the status of supplier rating, certification and selection systems in the US Defense Aircraft Industry. Our findings result from a range of information gathering activities over the past eighteen months including: Site ...
Shapiro, Jeremy F.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

A Persistent Simulation Environment for Autonomous Systems [PDF]

open access: yes
The age of Autonomous Unmanned Aircraft Systems (AUAS) is creating new challenges for the accreditation and certification requiring new standards, policies and procedures that sanction whether a UAS is safe to fly.
Allen, B. Danette   +4 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Comparison of Certification Authority Roles in Windows Server 2003 and Windows Server 2008

open access: yesБезопасность информационных технологий, 2011
An analysis of Certification Authority components of Microsoft server operating systems was conducted. Based on the results main directions of development of certification authorities and PKI were highlighted.
A. I. Luchnik
doaj  

The role of participatory Guarantee Systems for Food security [PDF]

open access: yes, 2015
The primary tool for assuring quality of organic products and preventing fraud, and also for promoting commerce, is third party organic certification, which aims to regulate and facilitate the sale of organic products to consumers.
Home, Robert, Nelson, Erin
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Farmers’ acceptance of further strengthening of private certification systems [PDF]

open access: yes
In their continuous quest for ecologic improvements, private voluntary certification initiatives might undermine the willingness to continue of the participating farmers. In this research, the ecologic contribution and the farmers’ acceptance of changing
Garreyn, F.   +3 more
core   +1 more source

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