Results 141 to 150 of about 563,065 (308)

LCA benchmarks in building's environmental certification systems [PDF]

open access: yes, 2016
The paper deals with the definition of reference values (benchmarks) referred to the Life Cycle Assessment (LCA) indicators used in the environmental certification systems of buildings (Green Building Rating Systems, energy-environmental certifications ...
Campioli, A., Ganassali, S., Lavagna, M.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

ECOROM – Indicators System Proposal of Quality Certification in Ecotourism [PDF]

open access: yes
Open to trends in tourism development on European and world level, Romanian tourism improves under its impact, developing specific recognition criteria at global level, regarding the quality of services and cultural and natural attractions it owns ...
Hornoiu Remus   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Enhancing Safety in Military Aviation: A Systematic Approach to the Development of AI Certification Standards

open access: yesEngineering Proceedings
This article proposes a systematic methodology for developing a certification standard for AI safety-critical systems in military aviation, combining military and civil airworthiness references.
Raquel Delgado-Aguilera Jurado   +5 more
doaj   +1 more source

Objectiveness in the Market for Third-Party Certification: Does market structure matter? [PDF]

open access: yes
The globalization of trade in high quality foods is stimulating the development of international food standards and certification systems. Third-party certification as evolved as a means of ensuring that product information and signals on quality and ...
Anders, Sven   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

System reliability and risk assessment task goals and status [PDF]

open access: yes
The major focus for continued development of the Numerical Evaluation of Stochastic Structures Under Stress (NESSUS) codes is in support of system testing and certification of advanced propulsion systems.
Cruse, T. A., Mahadevan, S.
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

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