Results 271 to 280 of about 1,570,097 (290)

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Determinants of delay in presentation to completion of treatment in cervical cancer. [PDF]

Sci Rep
Begum D, Bassetty KC, Barmon D, Baruah U, Nath J, Khanikar D, Roy PS, Bhattacharyya M, Ahmed S, Kumar M, Baruah C.   +10 more
europepmc   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Multi-omics reveals that NOTCH1 promotes cervical cancer progression and reduces radiosensitivity. [PDF]

Front Immunol
Guo A, Su Z, Zhang E, Lin H, Zhong P, Xie Z, Zhan Q, Ye T, Sun Y.   +8 more
europepmc   +1 more source

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

Advanced Science, EarlyView.
This study identifies that REGγ is elevated in obese adipose tissue. REGγ modulates WAT browning via ubiquitin‐independent ACADM/KLF15–UCP1 degradation. Overactivation of the NRF2–REGγ axis facilitates adipose tissue function to cause obesity. Inhibition of REGγ in the iWAT alleviates HFD‐induced obesity.
Hui Chen, Qiujing Guan, Shuangming Gong, Yingying Du, Zhidan Zhang, Yan Liu, Lei Zhou, Lin Liu, Baoquan Xin, Yilan Guo, Hui Zhang, Ziyang Zhou, Tongchao Pei, Guohong Yu, Sokun Yin, Lei Li   +15 more
wiley   +1 more source

Ultrasound-guided intermediate versus deep cervical plexus block for carotid endarterectomy: a randomized controlled study. [PDF]

BMC Anesthesiol
Turhan Ö, Sivrikoz N, Canbolat N, Demirel EE, Altun D, Sungur Z.   +5 more
europepmc   +1 more source

A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis

Advanced Science, EarlyView.
This study presents RotEx‐LAMP‐LFA, a fully integrated, battery‐powered, low‐cost point‐of‐care device for rapid cervical cancer risk detection based on HPV16/18 E6/E7 mRNA. Clinically validated, the system demonstrated high sensitivity and specificity, and showed full concordance between self‐collected and clinician‐collected samples, offering a ...
Yuan Gao, Qiang Wen, Siyuan Qiao, Linyi Deng, Keyue Li, Zhuyan Shao, Xiaonan Liu, Tao Zhu, Chao Zhang, Da Han, Weihong Tan   +10 more
wiley   +1 more source

Cervical strain elastography to predict response to labor induction at late-term pregnancy in nulliparous women: A prospective cohort study. [PDF]

Medicine (Baltimore)
Bütün Z, Kayapinar M, Şenol G, Salik EA, Dönmez EE.   +4 more
europepmc   +1 more source

Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair

Advanced Science, EarlyView.
This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang, Yiming Liam Liu, Yidi Augenstern Du, Shan−Shan Wang, Bo O. Zhou   +4 more
wiley   +1 more source

Impact of sarcopenia on postoperative clinical outcomes in patients with cervical spondylotic myelopathy undergoing anterior cervical discectomy and fusion. [PDF]

Eur J Med Res
Gong Y, Long X, Liu H, He J, Gan Y, Jiang Y, Zhuo H, Zhou Z, Tang K, Liang, Jiang X, Cheng Z, Liu J.   +12 more
europepmc   +1 more source