Results 181 to 190 of about 718,452 (353)

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Cervical cancer screening policies and implementation in Uganda - a qualitative study on policymakers', cervical cancer experts' and gynecologists' perspectives. [PDF]

Arch Public Health
De Paepe E, Nanyonjo G, Vermandere H, Ssetaala A, Degomme O.   +4 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Research progress of ferroptosis in cervical cancer treatment. [PDF]

Ann Med
Wang F, Wang L, Bai Y.
europepmc   +1 more source

Coping with Cervical Cancer in Adolescence: a Look from Psychology

, 2021
Laura Naranjo Hernández, Janet Villafuerte Reinante, Aymara Rodríguez Márquez   +2 more
openalex   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

What is the role of circRNAs in the pathogenesis of cervical cancer? A systematic literature review [PDF]

Ana Gabrielly de Melo Matos, Gyl Eanes Barros Silva, Eldevan da Silva Barbosa, Marcelo Souza de Andrade, Joyce Santos Lages, Rita da Graça Carvalhal Frazão Corrêa, Ana Gabriela Caldas Oliveira, Eliel Barbosa Teixeira, Marcelli Geisse de Oliveira Prata da Silva, Susanne Suely Santos da Fonseca, Antonio Augusto Lima Teixeira Júnior, Matheus Silva Alves, Antonio Machado Alencar, André Salim Khayat, Jaqueline Diniz Pinho   +14 more
openalex   +1 more source

Foxo3a-Mediated DNMT3B Impedes Cervical Cancer Cell Proliferation and Migration Capacities through Suppressing PTEN Promoter Methylation

, 2023
Hongying Li, Yuqin Yuan, Hong Dong, Tinghui Wang, Dunlan Zhang, Limin Zhou, Lu Chen, Xueyan He   +7 more
openalex   +1 more source