Results 191 to 200 of about 708,585 (354)

Laeverin is Cell‐Surface Target for Liquid‐Phase Metastasizing Cancer Cells

open access: yesAdvanced Science, EarlyView.
This study revealed that epithelial cancer cells in the floating phase induce the expression of laeverin (LVRN) that is a trophoblast‐specific and cell‐surface immunoregulatory factor and showed that anti‐LVRN ADC is a promising agent that can attack cancer cells in the metastatic liquid phase and block further distant metastasis.
Haruki Kasama   +17 more
wiley   +1 more source

Cytological Classification Diagnosis for Thyroid Nodules via Multimodal Model Deep Learning

open access: yesAdvanced Science, EarlyView.
This study introduces AI‐TFNA, an innovative artificial intelligence model designed to assist cytopathologists in classifying thyroid nodules based on The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The model effectively differentiates between benign and malignant thyroid nodules, demonstrating significant potential as a screening ...
Yuanzheng Lou   +27 more
wiley   +1 more source

Determinants of delay in presentation to completion of treatment in cervical cancer. [PDF]

open access: yesSci Rep
Begum D   +10 more
europepmc   +1 more source

Tumor Cell‐Derived CXCL2 Potentiates Neutrophil‐Mediated Antitumor Immunity by Inhibiting Cholesterol Biosynthesis in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
This study identifies the unconventional role of CXCL2 in regulating neutrophil polarization and immune responses in HCC. Unlike the common view that CXCL2 acts mainly as an extracellular chemokine, intracellular CXCL2 can interact with YBX1 and prevent its nuclear translocation.
Xin Liu   +13 more
wiley   +1 more source

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

open access: yesAdvanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou   +13 more
wiley   +1 more source

HPV-Independent Cervical Cancer-A New Challenge of Modern Oncology. [PDF]

open access: yesInt J Mol Sci
Hurjui RM   +5 more
europepmc   +1 more source

ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth

open access: yesAdvanced Science, EarlyView.
This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen   +10 more
wiley   +1 more source

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