Results 181 to 190 of about 609,595 (394)

Red Blood Cell Membrane‐Camouflaged Red Phosphorus‐Modified C3N4 for Enhanced Tumoral Photodynamic Therapy

open access: yesAdvanced Materials Interfaces, EarlyView.
Photodynamic therapy (PDT) faces clinical challenges due to poor tumor targeting and systemic toxicity. Herein, a biomimetic C3N4‐RP@RBCm nanoplatform is developed via erythrocyte membrane encapsulation, enabling CD47‐mediated immune evasion and EPR‐driven tumor accumulation.
Jiaxiu Liu   +9 more
wiley   +1 more source

Liquiritin Exerts a Dual Effect on BMSCs Osteogenic Differentiation and Fracture Healing by Activating the ERK/JNK Pathway and Providing Antioxidant Protection

open access: yesAdvanced Therapeutics, EarlyView.
Liquiritin enhances the osteogenic differentiation of BMSCs and promotes fracture healing through the activation of the ERK/JNK signaling pathway and by exerting antioxidant protective effects. Abstract Liquiritin, a flavonoid from Glycyrrhiza uralensis L., has diverse pharmacological properties, but its impact on fracture healing is unexplored.
Haijun Mao   +6 more
wiley   +1 more source

Cervical cancer and cervical screening

open access: yesReproductive Endocrinology, 2014
В статье представлены современные лабораторные аспекты цитологического исследования в рамках обеспечения эффективного цервикального скрининга: факторы влияния на качество цитологии, сравнение традиционной и жидкостной цитологии, вопросы стандартизации выдачи заключений цитологического исследования, в соответствии с системой Бетесда (The Bethesda System)
openaire   +2 more sources

Cytokine mRNA Delivery and Local Immunomodulation in the Placenta Using Lipid Nanoparticles

open access: yesAdvanced Therapeutics, EarlyView.
This article evaluates lipid nanoparticles to deliver immunomodulatory mRNA to placental cells and mouse placentas to study and treat the immune underpinnings of placenta‐related diseases. Lipid nanoparticles induce cytokine secretion and macrophage polarization toward an anti‐inflammatory state.
Samuel I. Hofbauer   +9 more
wiley   +1 more source

Chinese expert consensus on vaginal self-sampling with high-risk human papillomavirus testing for cervical cancer screening

open access: yesGynecology and Obstetrics Clinical Medicine
Cervical cancer is one of the most common cancers in women globally and remains the leading cause of cancer-related death among women in low- and middle-income countries. It is more prevalent in populations that are unscreened or underscreened. Improving
Linhong Wang   +11 more
doaj   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

open access: yesAdvanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang   +8 more
wiley   +1 more source

Preventing avoidable death: the case of cervical cancer in Hong Kong [PDF]

open access: yes, 1997
Cervical cancer remains an important cause of avoidable morbidity and mortality in Hong Kong. This paper briefly reviews the epidemiology of cervical cancer and explores the evidence on the effectiveness of screening.
Adab, P, Hedley, AJ
core  

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

open access: yesAdvanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi   +16 more
wiley   +1 more source

Cervical cancer in Region Skåne, Sweden 2017–2020 after the implementation of primary HPV screening: A quality assurance audit

open access: yesActa Obstetricia et Gynecologica Scandinavica
Introduction Primary human papilloma virus (HPV) screening to detect cervical cancer and dysplastic lesions was implemented in Region Skåne 2017 for women aged 30–70. The aim of this study was to characterize the screening history of women diagnosed with
Caroline Hellsten   +4 more
doaj   +1 more source

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