Results 251 to 260 of about 609,595 (394)

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska   +18 more
wiley   +1 more source

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

open access: yesAdvanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong   +27 more
wiley   +1 more source

Barriers to adherence to cervical cancer screening care in Northern Tanzania. [PDF]

open access: yesOncologist
Lyamuya T   +10 more
europepmc   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

open access: yesAdvanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria   +5 more
wiley   +1 more source

Refractive Index‐Corrected Light‐Sheet Microscopy for Macro‐View Cardiovascular Imaging

open access: yesAdvanced Science, EarlyView.
A refractive index‐corrected light‐sheet fluorescence microscopy system enables macro‐view cardiovascular imaging across organs, adapting to refractive index variations from different optical clearing protocols. By integrating axial sweeping, multi‐view imaging, and a sealed chamber, it extends the field of view, enhances isotropy, and improves safety.
Enbo Zhu   +13 more
wiley   +1 more source

Quality Assurance in Cervical Cancer Screening: Evaluation of Sample Adequacy in HPV DNA Testing. [PDF]

open access: yesJ Med Virol
d'Avenia M   +7 more
europepmc   +1 more source

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

open access: yesAdvanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong   +16 more
wiley   +1 more source

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