Results 11 to 20 of about 29,502 (239)
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem+6 more
wiley +1 more source
This study interpreted the differential profiles of cervicovaginal microbiota and CSTs between HC women and HPV16‐infected women with CIN I, CIN II/III or SCC. The relationship between HPV16 clearance and cervicovaginal microbiota composition in each disease stage before and after clinical treatments was also established.
Chao Li+3 more
wiley +1 more source
Abstract Genetic association analysis, which evaluates relationships between genetic markers and complex, heritable traits, is the basis of genome‐wide association studies. The many association tests that have been developed can generally be classified as prospective versus retrospective, parametric versus nonparametric, and genotype‐ versus allele ...
Lin Zhang, Lei Sun
wiley +1 more source
Objective To determine the prevalence and possible variables associated with anal intraepithelial neoplasia and anal cancer in immunocompetent women with high-grade cervical intraepithelial neoplasia.
Vivian de Oliveira Rodrigues Brum+4 more
doaj +1 more source
Cervical Optical Coherence Tomography Image Classification Based on Contrastive Self-Supervised Texture Learning [PDF]
Background: Cervical cancer seriously affects the health of the female reproductive system. Optical coherence tomography (OCT) emerged as a non-invasive, high-resolution imaging technology for cervical disease detection. However, OCT image annotation is knowledge-intensive and time-consuming, which impedes the training process of deep-learning-based ...
arxiv +1 more source
A Bayesian accelerated failure time model for interval censored three-state screening outcomes [PDF]
Women infected by the Human papilloma virus are at an increased risk to develop cervical intraepithalial neoplasia lesions (CIN). CIN are classified into three grades of increasing severity (CIN-1, CIN-2, and CIN-3) and can eventually develop into cervical cancer.
arxiv +1 more source
The possible role of bacterial vaginosis in the pathogenesis of cervical precancerous lesions
The role of papillomavirus infection in the development of precancerous diseases and cervical cancer is known. Bacterial vaginosis was found to induce the deficiency of immune response of the vaginal mucosa surface.
Kemine Uzel, Igor Lakhno
doaj +1 more source
Regulation of LCoR and RIP140 expression in cervical intraepithelial neoplasia and correlation with CIN progression and dedifferentiation [PDF]
Purpose!#!Ligand-dependent corepressor (LCoR) and receptor-interacting protein 140 (RIP140/NRIP1) play an important role in the regulation of multiple oncogenic signaling pathways and the development of cancer.
Blankenstein, Thomas+11 more
core +1 more source
Introduction. As is known, the development of invasive cervical cancer is preceded by cervical intraepithelial neoplasia of varying severity, which is a pathological process in which cells with varying degrees of atypia and impaired differentiation ...
L. V. Tkachenko+4 more
doaj +1 more source
Risk of cervical cancer after completed post-treatment follow-up of cervical intraepithelial neoplasia: Population based cohort study [PDF]
Objective To compare the risk of cervical cancer in women with histologically confirmed cervical intraepithelial neoplasia who returned to routine screening after having completed post-treatment follow-up with consecutive normal smear test results ...
Ballegooijen, M. (Marjolein) van+6 more
core +2 more sources