Results 11 to 20 of about 29,502 (239)

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

open access: yesCancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem   +6 more
wiley   +1 more source

Changes in the cervicovaginal microbiota composition of HPV16‐infected patients after clinical treatment

open access: yesCancer Medicine, Volume 11, Issue 24, Page 5037-5049, December 2022., 2022
This study interpreted the differential profiles of cervicovaginal microbiota and CSTs between HC women and HPV16‐infected women with CIN I, CIN II/III or SCC. The relationship between HPV16 clearance and cervicovaginal microbiota composition in each disease stage before and after clinical treatments was also established.
Chao Li   +3 more
wiley   +1 more source

Unifying genetic association tests via regression: Prospective and retrospective, parametric and nonparametric, and genotype‐ and allele‐based tests

open access: yesCanadian Journal of Statistics, Volume 50, Issue 4, Page 1321-1338, December 2022., 2022
Abstract Genetic association analysis, which evaluates relationships between genetic markers and complex, heritable traits, is the basis of genome‐wide association studies. The many association tests that have been developed can generally be classified as prospective versus retrospective, parametric versus nonparametric, and genotype‐ versus allele ...
Lin Zhang, Lei Sun
wiley   +1 more source

Cytology-based Screening for Anal Intraepithelial Neoplasia in Immunocompetent Brazilian Women with a History of High-Grade Cervical Intraepithelial Neoplasia or Cancer

open access: yesRevista Brasileira de Ginecologia e Obstetrícia, 2022
Objective To determine the prevalence and possible variables associated with anal intraepithelial neoplasia and anal cancer in immunocompetent women with high-grade cervical intraepithelial neoplasia.
Vivian de Oliveira Rodrigues Brum   +4 more
doaj   +1 more source

Cervical Optical Coherence Tomography Image Classification Based on Contrastive Self-Supervised Texture Learning [PDF]

open access: yesMedical Physics, 2022, 49 (6), 3638-3653, 2021
Background: Cervical cancer seriously affects the health of the female reproductive system. Optical coherence tomography (OCT) emerged as a non-invasive, high-resolution imaging technology for cervical disease detection. However, OCT image annotation is knowledge-intensive and time-consuming, which impedes the training process of deep-learning-based ...
arxiv   +1 more source

A Bayesian accelerated failure time model for interval censored three-state screening outcomes [PDF]

open access: yesAnn. Appl. Stat. 17(2): 1285-1306 (June 2023), 2021
Women infected by the Human papilloma virus are at an increased risk to develop cervical intraepithalial neoplasia lesions (CIN). CIN are classified into three grades of increasing severity (CIN-1, CIN-2, and CIN-3) and can eventually develop into cervical cancer.
arxiv   +1 more source

The possible role of bacterial vaginosis in the pathogenesis of cervical precancerous lesions

open access: yesАктуальні проблеми сучасної медицини, 2020
The role of papillomavirus infection in the development of precancerous diseases and cervical cancer is known. Bacterial vaginosis was found to induce the deficiency of immune response of the vaginal mucosa surface.
Kemine Uzel, Igor Lakhno
doaj   +1 more source

Regulation of LCoR and RIP140 expression in cervical intraepithelial neoplasia and correlation with CIN progression and dedifferentiation [PDF]

open access: yes, 2020
Purpose!#!Ligand-dependent corepressor (LCoR) and receptor-interacting protein 140 (RIP140/NRIP1) play an important role in the regulation of multiple oncogenic signaling pathways and the development of cancer.
Blankenstein, Thomas   +11 more
core   +1 more source

Immunological substantiation of complex therapy in patients with mild HPV-associated cervical intraepithelial neoplasia

open access: yesМедицинский совет, 2022
Introduction. As is known, the development of invasive cervical cancer is preceded by cervical intraepithelial neoplasia of varying severity, which is a pathological process in which cells with varying degrees of atypia and impaired differentiation ...
L. V. Tkachenko   +4 more
doaj   +1 more source

Risk of cervical cancer after completed post-treatment follow-up of cervical intraepithelial neoplasia: Population based cohort study [PDF]

open access: yes, 2012
Objective To compare the risk of cervical cancer in women with histologically confirmed cervical intraepithelial neoplasia who returned to routine screening after having completed post-treatment follow-up with consecutive normal smear test results ...
Ballegooijen, M. (Marjolein) van   +6 more
core   +2 more sources

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