Results 81 to 90 of about 4,564,348 (291)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

A prospective study of cervical length measurement in predicting preterm delivery [PDF]

, 2008
To study the cervical length measurement in relation to the outcome of pregnancy.All patients who attended HUSM antenatal clinic and those who are fulfilled all the criteria listed are recruited in this study.
Norlidar, Mohamed
core   +1 more source

MAVARIC - a comparison of automation-assisted and manual cervical screening: a randomised controlled trial. [PDF]

, 2011
OBJECTIVES: The principal objective was to compare automation-assisted reading of cervical cytology with manual reading using the histological end point of cervical intraepithelial neoplasia grade II (CIN2) or worse (CIN2+). Secondary objectives included
G Dunn, S Moss, MAVARIC Trial Study Group, R Blanks, Sadique, A, Sadique, Z, Kitchener, HC, Dunn, G, A Gray, Moss, S, M Desai, Cubie, H, Blanks, R, R Legood, Legood, R, Desai, M, H Cubie, Desia, M, Z Sadique, Gray, A, HC Kitchener   +20 more
core   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Efficacy of early cervical length screening in pregnant women with cervical excision

Гинекология
Background. Excisional treatments for cervical pathology, such as loop excision of the transformation zone (LLETZ) and conization, are widely used in women of reproductive age. However, they are associated with an increased risk of cervical insufficiency
Yulia E. Dobrokhotova, Irina A. Lapina, Kamila T. Bekmurzaeva, Darina A. Khamurzova   +3 more
doaj   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Comparison of the Cervical Length during Second Trimester of Pregnancy between Teenage and Adult Primigravidae

Thai Journal of Obstetrics and Gynaecology, 2016
Objective:To compare cervical length at midgestation (18+0 - 23+6 weeks of gestation) between primigravida teenage (
Noochanart Pattanapanyasat, Somnimit Luengratsameerung, Paiboon Charoenchainont   +2 more
doaj   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Accuracy and efficacy of embryo transfer based on the previous measurement of cervical length and total uterine length

, 2019
Purpose: Aim of the study was to examine the accuracy of embryo transfer based on the previous measurement of cervical length and total uterine length. Methods: The study has taken place in an academic-assisted reproduction clinic.
Bakas, P., Simopoulou, M., Giner, M., Tzanakaki, D., Deligeoroglou, E.   +4 more
core   +1 more source