Results 111 to 120 of about 222,132 (339)
Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD
Advanced Science, EarlyView.Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du +6 more
wiley +1 more source
Experimentally based numerical models and numerical simulation with parameter identification of human lumbar FSUs in traction [PDF]
, 2004 Numerical simulation of the behaviour of human lumbar spine segments, moreover, parameter-identification of the component organs of human lumbar FSUs are presented in traction therapies, by using FEM analysis. First, a simple 2D model, than a refined 2D
Kurutzné Kovács, Márta, Tornyos, A.
core
Advanced Science, EarlyView.This study presents a novel “in vivo–in vitro” therapeutic strategy for spinal cord injury by leveraging magnetically responsive piezoelectric nanomaterials. These nanomaterials enable targeted delivery of localized electrical stimulation at the injury site through noninvasive external magnetic actuation, thereby promoting axonal regeneration and ...
Zhihang Xiao +9 more
wiley +1 more source
Current Concepts in Pediatric Cervical Spine Trauma [PDF]
, 2017 Kunal Shah +3 more
openalex +1 more source
Der Radiologe, 2017 In the emergency department 65 % of spinal injuries and 2-5 % of blunt force injuries involve the cervical spine. Of these injuries approximately 50 % involve C5 and/or C6 and 30 % involve C2. Older patients tend to have higher spinal injuries and younger patients tend to have lower injuries.
Yilmaz, U., Hellen, Peter
openaire +2 more sources
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication
Advanced Science, EarlyView.Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song +11 more
wiley +1 more source
Posterior Cervical Spine Crisscross Fixation: Biomechanical Evaluation [PDF]
, 2018 Background Biomechanical/anatomic limitations may limit the successful implantation, maintenance, and risk acceptance of posterior cervical plate/rod fixation for one stage decompression-fusion.
Cheng, Joseph S. +4 more
core +1 more source