Results 111 to 120 of about 223,461 (361)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Large‐Scale Quantitative Morphometry of Platelet α‐Granules via SIM Super‐Resolution Microscopy for Cancer Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Blood‐based liquid biopsies hold transformative potential for non‐invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating diverse cancer‐associated responses, represent a compelling yet largely unexplored alternative.
Yan Ma, Huan Deng, Zelin Liu, Simei Zhong, Liangliang Wang, Mu He, Ning Jing, Lihua Dai, Yuzhen Basang, Xiao‐Yu Hu, Changyi Zhang, Huimin Zeng, Haoren Shao, Zhe Yang, Shanshan Zhao, Xiaohai Hu, Chuanjie Zhang, Xiaowei Wu, Jing Xu, Shaoqun Zeng, Jing Yuan, Qiang Li, Ziwei Qu, Zhenya Hong, Lingjuan Chen, Hanhua Dong, Jia Guo, Zhiqiang Han, Yu‐Hui Zhang   +28 more
wiley   +1 more source

Traumatic spinal cord injury caused by suspected hyperflexion of the atlantoaxial joint in a 10-year-old cat [PDF]

, 2015
Case summary: A 10-year-old cat presented 5 days after a traumatic event with acute recumbency followed by some clinical improvement. The neuroanatomical localisation was the C1–C5 spinal cord segments.
Hammond, Gawain, McLaughlin, Angela, Wessmann, Annette   +2 more
core   +2 more sources

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source

Tumoral calcinosis in the cervical spine: a case report and review of the literature

Journal of Medical Case Reports, 2017
Background Tumoral calcinosis is rarely located in spine. A 55-year-old Japanese woman with cervical tumoral calcinosis is presented, along with a review of the literature relating to tumoral calcinosis in the spine. We discussed the etiology, diagnosis,
Rui Guo, Tatsuya Kurata, Tetsushi Kondo, Takao Imanishi, Tetsutaro Mizuno, Toshihiko Sakakibara, Yuichi Kasai   +6 more
doaj   +1 more source

Erratum: Screening via CT angiogram after traumatic cervical spine fractures: narrowing imaging to improve cost effectiveness. Experience of a Level I trauma center [PDF]

, 2016
Gabriel A. Smith
openalex   +1 more source

Smart Flexible Tactile Sensors: Recent Progress in Device Designs, Intelligent Algorithms, and Multidisciplinary Applications

Advanced Intelligent Discovery, EarlyView.
Flexible tactile sensors have considerable potential for broad application in healthcare monitoring, human–machine interfaces, and bioinspired robotics. This review explores recent progress in device design, performance optimization, and intelligent applications. It highlights how AI algorithms enhance environmental adaptability and perception accuracy
Siyuan Wang, Ming Dong, Rongrong Bao, Caofeng Pan   +3 more
wiley   +1 more source

The AO Spine RECODE-DCM International Collaborative—Establishing the Foundations for Accelerated and Patient-Centered Innovation

Global Spine Journal, 2022
Danyal Z. Khan MRCS, Olesja Hazenbiller MSc, Toto Gronlund MSc, Iwan Sadler, Ellen B. Sarewitz MA, Oliver Mowforth MRCS, Mark R. N. Kotter FRCS, PhD, Benjamin M. Davies MRCS, BSc, MPhil   +7 more
doaj   +1 more source

Does inter-vertebral range of motion increase after spinal manipulation? A prospective cohort study. [PDF]

, 2014
Background: Spinal manipulation for nonspecific neck pain is thought to work in part by improving inter-vertebral range of motion (IV-RoM), but it is difficult to measure this or determine whether it is related to clinical outcomes.
A Aho, A Field, A Simpson, AC Breen, AK Deitz, AM Leaver, AY Neziri, B Lind, D Nansel, DH Peterson, EL Hurwitz, F Antonaci, F Mellor, F Ohberg, G Bronfort, H Tilscher, HCW de Vet, HS Bahat, HT Vernon, J Cohen, J Dvorak, J Guzman, J Miller, JAJ Borghouts, JD Cassidy, JE Bolton, JT Farrar, JW Fielding, L Vogt, M Herdman, M Tousignant, ME Woesner, N Bogduk, P Cote, P Hudak, P Sjolander, PD Cote, PE Shrout, R Evans, R Martinez-Segura, S Dagenais, S Hogg-Johnson, V Feipel, W Frobin   +43 more
core   +1 more source