Results 201 to 210 of about 106,470 (262)

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

open access: yesAdvanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu   +12 more
wiley   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

open access: yesAdvanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou   +10 more
wiley   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

open access: yesAdvanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku   +4 more
wiley   +1 more source

Vasectomy and Cancer of the Cervix

New England Journal of Medicine, 1979
PIP: Swan and Brown in a recent issue of the New England Journal of Medicine reported a lower rate of sterilization among patients with cervical cancer or their partners than among matched controls. The major part of this difference was attributed to vasectomies, since 4.3% of patients with cervical cancer, as compared with 19.4% of matched controls ...
S H, Swan, W L, Brown
openaire   +4 more sources

Immunotherapy in cervix cancer

Cancer Treatment Reviews, 2020
The treatment approach to cervix cancer has remained unchanged for several decades and new therapeutic strategies are now required to improve outcomes, as the prognosis is still poor. In the last years, a better understanding of HPV tumor-host immune system interactions and the development of new therapeutics targeting immune checkpoints generated ...
Laura Attademo   +14 more
openaire   +2 more sources

Cancer of the Cervix

New England Journal of Medicine, 1969
Of the 325000 cancer deaths the American Cancer Society predicts for 1969 9700 will be cancer of the cervix. During the past 25 years early diagnosis and advanced therapy have reduced the adjusted death rate from uterine cancer by 50%. Contributing factors are believed to be low socioeconomic status early age of first coitus and a contribution from ...
openaire   +2 more sources

Cancer of the Uterine Cervix

New England Journal of Medicine, 1996
Invasive cervical cancer is uncommon in the United States, with an incidence of 15,800 cases and 4800 deaths in 1995.1 This relatively low incidence is largely due to the effectiveness of screening programs that assess cervical cytology by Pap smear. On a global scale, however, cancer of the cervix is a major cause of death, especially in Third World ...
S A, Cannistra, J M, Niloff
openaire   +2 more sources

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