Results 181 to 190 of about 86,968 (315)

The pathoanatomy of cancer: order in paradox. [PDF]

EBioMedicine
Höckel M.
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

A Synchronous Occurrence of Serous and Mucinous Cystadenomas of the Ovaries: Case Report and Review of the Literature. [PDF]

Int Med Case Rep J
Mbabazi E, Dushimiyimana B, Ruzindana K, Musana FRM, Getaneh FB, Manirakiza F.   +5 more
europepmc   +1 more source

MCV/Q, Medical College of Virginia Quarterly, Vol. 11 No. 4 [PDF]

, 1975

core   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Acute Polyradiculoneuropathy in a Patient With Squamous Cell Carcinoma of the Cervix: A Diagnostic Challenge. [PDF]

Cureus
Abourachida I, Klevor R, Chraa M, Kissani N, Louhab N.   +4 more
europepmc   +1 more source

MCV/Q, Medical College of Virginia Quarterly, Vol. 16 No. 1 [PDF]

, 1980

core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

From cervix to multisite: Detection of lower genital tract lesions in a 10-year cross-sectional colposcopy clinic study. [PDF]

PLoS One
Yan Z, Guo C, Liu Y, Li J, Lu Q, Li R, Feng B, Wang C, Li C, Shi L, Feng T, Wang Z, Feng R.   +12 more
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source