Results 241 to 250 of about 86,968 (315)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Rare case of primary HPV negative vaginal cancer presenting in a young woman with normal cervix. [PDF]

Gynecol Oncol Rep
Carter E, Nguyen-Guo T, Guta P, Soni V, McEachron J.   +4 more
europepmc   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Human papillomavirus (HPV) genotypes extended prevalence in the female population from a city in Northern Chile. [PDF]

BMC Womens Health
Escobar V, Catalán A, Callejas V, Araya R, Rojas J, García J, Alday A, Martin T, Santoro K, Campillay-Véliz C, Muñoz CA.   +10 more
europepmc   +1 more source

Spindle-cell variant of diffuse large B-cell lymphoma in the uterine cervix: a case report and literature review. [PDF]

J Clin Exp Hematop
Ikemoto A, Uchiyama T, Takeda M, Nakamine H, Yoshizawa A.   +4 more
europepmc   +1 more source

TPM3-NTRK1 Fusion Cervical Sarcoma: A Case Report of a Novel Subset of Gynaecological Sarcomas and Successful Treatment of Recurrent Disease With Trk-Inhibition Therapy. [PDF]

Cureus
Lowe-Zinola J, Elghobashy M, Evans M, Hafeez T, El-Ghobashy A.   +4 more
europepmc   +1 more source

De novo malignant tumors in organ transplant recipients. [PDF]

, 1971
Halgrimson, CG, Penn, I, Starzl, TE
core  

Analysis of factors associated with cervical cancer and precancerous lesions. [PDF]

Sci Rep
Hu D, Zhao Y, Han M, Qian W, Xu X, Sheng S.   +5 more
europepmc   +1 more source

Efficacy of FOXP3+Treg cells combined with platelet in predicting recurrence of cervical cancer: a retrospective study. [PDF]

BMC Womens Health
Min S, Xie L, Wu Y, Bo L, Liu Y, Zhu Y, Tan Y.   +6 more
europepmc   +1 more source

Nonmelanomatous Skin Cancer Following Cervical, Vaginal, and Vulvar Neoplasms: Etiologic Association [PDF]

, 2017
La Vecchia, Carlo, La Vecchia, Carlo, Levi, Fabio, Randimbison, Lalao   +3 more
core