Results 81 to 90 of about 86,968 (315)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Study of Frequency of High Grade Cervical Intraepithelial Neoplasms (CIN 2, 3) in Patients Infected with Uncommon High Risk Human Papillomavirus

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Despite the significant relationship between human papillomavirus 16 and 18 subtypes and severe cases of cervical cancer, the assessing the frequency of high-grade cervical intraepithelial neoplasms in the patients infected with high-risk ...
Fahimeh Sabet, Fariba Behnamfar, Narjes Khalili, Farnaz Baba Haji Meybodi   +3 more
doaj  

Causes of adult deaths in developing countries : a review of data and methods [PDF]

Relatively little attention has been paid to the problem of premature adult mortality in developing countries, despite high levels of mortality in many countries - and despite the potentially severe social and economic consequences of adult deaths ...
Hayes, Richard, Lockett, Geraldine, Mertens, Thierry, Rodrigues, Laura   +3 more
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Human Papillomavirus DNA in women having low-grade squamous intraepithelial lesion Tipificación del virus del papiloma humano en mujeres con lesión escamosa intraepitelial de bajo grado

Revista Colombiana de Obstetricia y Ginecología, 2006
Objective: to determine the prevalence and types of HPV in women with low-grade squamous intraepithelial lesions (LSIL). Methods: ninety-six women were sequentially enrolled from the colposcopy clinic.
Maria del Refugio González-Losa, Iván Rosado-López, Nina Valadez-González, Javier Cámara-Mejía, Marylin Puerto-Solís   +4 more
doaj  

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [PDF]

, 1996
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of
Aster, Jon C., Baltimore, David, Hasserjian, Robert P., Pear, Warren S., Scott, Martin L., Sklar, Jeffrey, Soffer, Benny   +6 more
core  

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Calidad del Programa de Detección Oportuna de Cáncer Cervicouterino en el estado de Nuevo León Quality of the Early Cervical Cancer Detection Program in the state of Nuevo León

Salud Pública de México, 1997
Objetivo. Determinar la calidad del Programa de Detección Oportuna de Cáncer Cervicouterino en Nuevo León. Material y métodos. Se analizaron 4 791 informes citológicos emitidos por los módulos de detección oportuna de la Secretaría de Salud Estatal, el ...
ANA MARÍA SALINAS-MARTÍNEZ, ENRIQUE VILLARREAL-RÍOS, MARÍA EUGENIA GARZA-ELIZONDO, JUAN MANUEL FRAIRE-GLORIA, J. JESÚS LÓPEZ-FRANCO, ORALIA BARBOZA-QUINTANA   +5 more
doaj  

Epidemiological Features of HPV-Associated Cancer in situ of Various Localization

Эпидемиология и вакцинопрофилактика
Relevance. In Russia and abroad, the incidence of cancer in situ (CIS) of the breast and cervix is most widely represented, the epidemiological features of this neoplasia of other localizations have not been studied sufficiently.
D. V. Kholopov, L. V. Lyalina, V. V. Khizha, E. E. Topuzov, T. G. Zadorkina   +4 more
doaj   +1 more source