Results 61 to 70 of about 107,934 (310)

Recent advances in the construction of humanized animal models and applications in translational medicine

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Cesarean, ever to need attention: Prevalence and causes of cesarean section in Jahrom, 1387

open access: yesفصلنامه دانشگاه علوم پزشکی جهرم, 2011
Introduction: The main reason for the choice of cesarean section delivery is to save the life or health of the mother and her baby. However, cesarean section is not without complications, either for the mother or the baby.
Karamat Rahmanian   +2 more
doaj  

Evaluating the ‘Focus on Normal Birth and Reducing Caesarean section Rates Rapid Improvement Programme’: A mixed method study in England

open access: yes, 2015
Background Caesarean section plays an important role in ensuring safety of mother and infant but rising rates are not accompanied by measurable improvements in maternal or neonatal mortality or morbidity.
Marshall, Joyce   +3 more
core   +1 more source

Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection

open access: yesThe Anatomical Record, EarlyView.
Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson   +6 more
wiley   +1 more source

Historical birth records from 1896 to 1944 from the Basel maternity hospital, Switzerland, reveal significant obstetric selection pressures

open access: yesThe Anatomical Record, EarlyView.
Abstract Maternal and neonatal morbidity and mortality have declined dramatically during the last century. Historical data are therefore important sources to study the evolutionary selection pressures related to childbirth and how they have fluctuated over time.
Mirella Woodert   +7 more
wiley   +1 more source

The Association Between Medical Factors During Pregnancy and Cesarean Section in Bandar Abbas-Prospective Cohort [PDF]

open access: yesJournal of Advanced Biomedical Sciences, 2020
Background & Objectives: Cesarean section rates have increased significantly over the past decade. This increase has not been clinically justified. The objective of this study was to investigate the effect of medical factors on the type of delivery ...
Fatemeh Sharifnia   +2 more
doaj  

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga   +20 more
wiley   +1 more source

Histopathological evaluation of cesarean scar defect in women with cesarean scar syndrome

open access: yes, 2022
滋賀医科大学博士(医学)pdfPurpose: To explore the histopathological findings of cesarean scar defect (CSD) and the immunological component in women with cesarean scar syndrome (CSS).Methods: This retrospective study was conducted in a university hospital and a ...
HIGUCHI, Asuka, 樋口, 明日香
core   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf   +6 more
wiley   +1 more source

An ecological study of geographic variation and factors associated with cesarean section rates in South Korea

open access: yesBMC Pregnancy and Childbirth, 2019
Background Korea is in a condition where the impact of patient and supplier factors on cesarean section rates can be clearly described. The cesarean section rates in Korea are among the highest in the world while the number of obstetricians is decreasing
Agnus M. Kim   +4 more
doaj   +1 more source

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