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A new treatment of alopecia induced by palbociclib: Topical cetirizine
Journal of Oncology Pharmacy Practice, 2020Introduction Recently CDK4/6 inhibitors have been introduced for the treatment of hormone positive breast cancer resistant to endocrine therapy. Among their side effects, alopecia is often reported being associated to patients’ distress and depressive ...
G. Caro +5 more
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Cetirizine: Actions on neurotransmitter receptors
Journal of Allergy and Clinical Immunology, 1990First-generation H1-antagonist antihistamines, such as hydroxyzine, have the ability to cross the blood-brain barrier and cause sedation, which limits their usefulness in the treatment of allergic disorders. Cetirizine, a carboxylated metabolite of hydroxyzine, possesses the parent compound's antihistaminic activity but causes less sedation.
Solomon H. Snyder, Adele M. Snowman
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Cetirizine: A piperazine antihistamine
Clinics in Dermatology, 1991Abstract Cetirizine (2-(2-(4-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic acid dihydrochloride) (Fig 1) is the principal human metabolite of hydroxyzine (Fig 2), a member of the piperazine class of antihistamines. It is a selective H1 histamine receptor antagonist, which has been shown to be effective in the treatment of urticaria and ...
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Journal of Microencapsulation, 2020
Aim: This work aimed to develop topical nanoemulsion gels of cetirizine, a second-generation antihistamine, to avoid its oral intake drawbacks and enhance skin permeation.
M. Kassem +2 more
semanticscholar +1 more source
Aim: This work aimed to develop topical nanoemulsion gels of cetirizine, a second-generation antihistamine, to avoid its oral intake drawbacks and enhance skin permeation.
M. Kassem +2 more
semanticscholar +1 more source
Urticarial intolerance reaction to cetirizine
Clinical and Experimental Dermatology, 2002The paradoxical acute exacerbation of pre-existing chronic idiopathic urticaria accompanied by intense generalized pruritus, facial oedema, and dyspnoea in a 36-year-old-woman 3-4 h after a single oral dose of 10 mg cetirizine (Zyrtec tablets), suggested the presence of an underlying intolerance reaction.
S. Schröter +2 more
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Use of cetirizine in dermatologic disorders
Annals of Allergy, Asthma & Immunology, 1999This review is written to summarize the present state of knowledge on the use of cetirizine in dermatologic disorders, its efficiency, and concerns regarding the safety of the drug.A Medline search from 1980 until August 1997 was conducted. In addition, older literature especially concerning hydroxyzine was evaluated as well.
Torsten Zuberbier, Beate M. Henz
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Cetirizine, a Novel Antihistamine
American Journal of Rhinology, 1987Cetirizine, an oxidative metabolite of hydroxyzine, is a cyclizine class H1-receptor antagonist with diminished CNS activity currently under investigation. It has a novel pharmacokinetic profile with a 9-hour half-life, lower volume of distribution and total body clearance, minimal metabolism and essentially renal excretion.
Robert Altman, Sheldon L. Spector
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Materials Research Express, 2019
Quantification of bioactive compounds via electrochemical methods is a topic of great interest over the past decades, due to its versatility and accuracy of estimation at the trace level.
N. Shetti +3 more
semanticscholar +1 more source
Quantification of bioactive compounds via electrochemical methods is a topic of great interest over the past decades, due to its versatility and accuracy of estimation at the trace level.
N. Shetti +3 more
semanticscholar +1 more source
Fundamental & Clinical Pharmacology, 2001
The primary objective of the present study was to compare the absorption and disposition of levocetirizine, the eutomer of cetirizine, when administered alone (10 mg) or in presence of the distomer. An additional objective was also to investigate the configurational stability of levocetirizine in vivo in humans. The study was performed in a randomized,
Gudrun Voss +5 more
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The primary objective of the present study was to compare the absorption and disposition of levocetirizine, the eutomer of cetirizine, when administered alone (10 mg) or in presence of the distomer. An additional objective was also to investigate the configurational stability of levocetirizine in vivo in humans. The study was performed in a randomized,
Gudrun Voss +5 more
openaire +3 more sources
Acta bio-medica : Atenei Parmensis, 2020
Background and aim: Seasonal allergic rhinitis (SAR) is a common disease in childhood that is characterized by bothersome symptoms and impaired quality of life (QoL).
M. Benazzo +8 more
semanticscholar +1 more source
Background and aim: Seasonal allergic rhinitis (SAR) is a common disease in childhood that is characterized by bothersome symptoms and impaired quality of life (QoL).
M. Benazzo +8 more
semanticscholar +1 more source