Results 111 to 120 of about 125,787 (301)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe, Julia A. Rocereta, Ruth A. Pumroy, Andreas Leffler, Michael Schaefer, Vera Moiseenkova‐Bell, Kerstin Hill   +6 more
wiley   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, EarlyView.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

Online legacy preservation for humanities researchers [PDF]

, 2014
As researchers retire or pass away, the online record of their work and their research careers begins to fragment and fade away. We begin with case studies of four New Zealand Humanities researchers, nearing or at the ends of their active careers.
Cunningham, Sally Jo, Nichols, David M.
core   +1 more source

Risk of progression to type 2 diabetes or regression to normoglycaemia among Ghanaians with prediabetes living in Ghana and the Netherlands: The RODAM prospective study

Diabetic Medicine, EarlyView.
Abstract Introduction Evidence shows that ethnicity affects the risk of progression of prediabetes to type 2 diabetes(T2D) or regression to normoglycaemia However, little is known about progression rates among sub‐Saharan African populations or whether geographical context affects risk variations.
Emmanuel Bannerman‐Williams, Yacoba Atiase, Bert‐Jan H. van den Born, Felix Patience Chilunga, Eva van der Linden, Karlijn A. C. Meeks, Erik Beune, Charles Agyemang, Charles Frederick Hayfron‐Benjamin   +8 more
wiley   +1 more source

Does an optimistic tone in annual reports predict better financial and non‐financial performance?

European Management Review, EarlyView.
Abstract In the current paper, we investigate whether management adopts an optimistic disclosure tone to impress the corporate audience or to provide incremental information (II) by anticipating positive corporate performance. Specifically, we test whether an optimistic tone in annual reports (ARs) is a positive predictor of better financial and non ...
Francesco Gangi, Daniele Angelo Previati, Lucia Michela Daniele, Giuseppe Galloppo   +3 more
wiley   +1 more source

Buffering roles of financial resilience in navigating family stress and adolescent distress: A conditional process analysis

Family Relations, EarlyView.
Abstract Objective This study examined the buffering roles of financial resilience in serial mechanisms between family economic adversity and adolescent psychological distress. Background Resilience factors are assumed to buffer family stress processes, although previous studies have primarily discussed the psychological rather than financial aspects ...
Zewei Liu, Ji‐Kang Chen
wiley   +1 more source

Marketing Strategy‐Based Fishers' Segmentation: The Key to Sustainable Fisheries Sector

Fisheries Management and Ecology, EarlyView.
ABSTRACT This paper attempts to empirically investigate potentially significant differences in perceptions regarding marketing strategies that could enhance economic and environmental sustainability in the sector based on the Structure—Conduct and Performance (SCP) methodological framework.
Eleni Kaimakoudi, Angelos Liontakis, Stamatis Mantziaris, Irene Tzouramani   +3 more
wiley   +1 more source

Genetic Determinants of Peanut‐Specific IgG4 Levels in the Context of Sustained Oral Peanut Exposure in the LEAP Study

Immunology, EarlyView.
A cumulative genetic score based on IgG4‐associated variants explains a substantial proportion of variance in psIgG4 levels during sustained peanut consumption, highlighting strong gene‐by‐environment interactions. Our findings suggest that early, sustained peanut consumption, in combination with genetic factors, promotes a protective immune response ...
Kanika Kanchan, Karen Cerosaletti, James A. Perry, George DuToit, Monali Manohar, Hua Ling, Justin E. Paschall, Srinath Sanda, R. Sharon Chinthrajah, Gerald T. Nepom, Kari C. Nadeau, Stacie M. Jones, Gideon Lack, Ingo Ruczinski, Rasika A. Mathias   +14 more
wiley   +1 more source