Results 141 to 150 of about 125,787 (301)
Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation
Plant, Cell &Environment, EarlyView.ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner +10 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu +7 more
wiley +1 more source
Utility of local capillary supply indices: Insights from computational image‐based modelling
The Journal of Physiology, EarlyView.Abstract figure legend Local capillary distribution and fibre geometry influence oxygen availability in skeletal muscle. Image‐based modelling of tissue PO2${{P}_{{{{\mathrm{O}}}_2}}}$ shows that area‐based measures of capillary supply – the local capillary density (LCDi) and local maximum diffusion distance (Dmax,i) – most accurately represent the ...
Abdullah A. Al‐Shammari +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li +19 more
wiley +1 more source
Development and Characterization of Mesoporous Activated Carbon From Cassia fistula Waste
Analytical Science Advances, Volume 7, Issue 1, June 2026.ABSTRACT Waste derived from the Cassia fistula tree, including pods, leaves and bark, was used as a starting material for the synthesis of mesoporous activated carbon (M‐AC) through a single‐step chemical activation process. Characterization of the samples was confirmed by using SEM, XRD, BET, FTIR and EDX analysis.
Bushra Hafeez +9 more
wiley +1 more source
Intelligent microneedle patch with cobalt-iron Prussian blue nanozymes for accelerating diabetic wound healing <i>via</i> heme biosynthesis-driven immunomodulation. [PDF]
Bioact MaterZhu Y, Kuang Y, Miao R, Ning M, Chen H.
europepmc +1 more source