Results 181 to 190 of about 81,604 (317)

Activation of 3-Phosphoinositide-dependent Kinase 1 (PDK1) and Serum- and Glucocorticoid-induced Protein Kinase 1 (SGK1) by Short-chain Sphingolipid C4-ceramide Rescues the Trafficking Defect of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (ΔF508-CFTR) [PDF]

, 2014
H. Caohuy, Qingfeng Yang, Yvonne Eudy, Thien-An Ha, Andrew E. Xu, Matthew L. Glover, Raymond A. Frizzell, Catherine Jozwik, Harvey B. Pollard   +8 more
openalex   +1 more source

Functional CFTR Activity in a Model of Regenerating Intestinal Crypts

, 2011
Jinghua Liu, Nancy M. Walker, Erin E. Hoover, Lane L. Clarke   +3 more
openalex   +1 more source

Exploring Exercise as Airway Clearance in Cystic Fibrosis: A Qualitative Study From the ExACT‐CF Feasibility Trial

Pediatric Pulmonology, Volume 61, Issue 1, January 2026.
ABSTRACT Question Cystic fibrosis (CF) affects > 11,300 people in the UK and is characterized by thick, sticky mucus in the lungs, leading to recurrent infections, inflammation, and progressive respiratory decline. Chest physiotherapy remains a cornerstone of airway clearance; however, many people with CF (pwCF) find it burdensome and time‐consuming ...
Emily Taylor, Dia Soilemezi, Don S. Urquhart, Steve Cunningham, Steff Lewis, Aileen Rae Neilson, Hannah Ensor, Ioannis Vogiatizis, Lorna Allen, Zoe L. Saynor, the ExACT‐CF study group, Don S. Urquhart, Emily Taylor, Steve Cunningham, Steff Lewis, Aileen Rae Neilson, Dia Soilemezi, Hannah Ensor, Ioannis Vogiatizis, Lorna Allen, Debbie Miller, Donna Bowen, Ellyse Kilarski, Ellen Lacey, Gary Connett, Julian Legg, Hazel Evans, Thomas Daniels, Mark Allenby, Mary Carroll, Robert Gray, Carlos Echevarria, Lisa Morrison, Gordon McGregor, Mary Abkir, Clare Saunders, Zoe L. Saynor   +36 more
wiley   +1 more source

Primary human intestinal organoids with biallelic UNC45A variants suggest role of cystic fibrosis transmembrane conductance regulator in pathogenesis of UNC45A‐related intestinal disorder

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 1, Page 70-73, January 2026.
April Rose Foster, Natasha G., Rebecca Harris, Matthias Zilbauer, Alexander Ross   +4 more
wiley   +1 more source

CFTR mechanism [PDF]

Nature, 1992
M. A. McPHERSON, R. L. DORMER
openaire   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, Volume 10, Issue 2, 22 January 2026.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

β‐Hydroxybutyrate Acts as an Exercise Mimetic to Protect the Aging Liver

Aging Cell, Volume 25, Issue 1, January 2026.
β‐hydroxybutyrate (β‐HB) acts as an exercise mimetic to protect the aging liver. In aged models, exercise‐induced β‐HB delays liver aging by reversing macrophage senescence, blocking mtDNA/cGAS‐STING‐driven inflammation, and alleviating hepatocyte lipid deposition/PANoptosis.
Ke Li, Lian Wang, Danlin Zhu, Wenhong Wang, Yifan Guo, Haoyang Gao, Muge Zhou, Weihua Xiao   +7 more
wiley   +1 more source

UK Biobank: Transforming drug discovery and precision medicine

British Journal of Pharmacology, Volume 183, Issue 2, Page 234-248, January 2026.
UK Biobank is a large‐scale, prospective study with extensive genetic and phenotypic data on half a million individuals. Volunteers, aged between 40 and 69 years, were recruited between 2006 and 2010 from the general population of the United Kingdom.
Jelena Bešević, Saredo Said, Reka Nagy, Yalda Jamshidi, Christopher D. Whelan, Lauren Carson, Martin K. Rutter, Adam J. Lewandowski, Mark Effingham, Rory Collins, Ben Lacey, Naomi E. Allen   +11 more
wiley   +1 more source

Pediatric Lung Waitlist Score (PLWS): A Score to Predict Waitlist Time for Pediatric Lung Transplant Candidates

Clinical Transplantation, Volume 40, Issue 1, January 2026.
ABSTRACT Background: In pediatric lung transplantation, the ability to estimate the projected waiting time could be particularly helpful for candidates and physicians. A score to predict waiting time has yet to be developed in this field. The purpose of this study was to create a score that predicts waitlist time for pediatric patients who are listed ...
Jose Ramirez, Spoorthi Kamepalli, Abbas Rana   +2 more
wiley   +1 more source

RFFL antisense oligonucleotides: A novel stabilization strategy to broaden the reach of CFTR modulator therapy. [PDF]

Mol Ther Nucleic Acids
Pedemonte N.
europepmc   +1 more source