Results 61 to 70 of about 81,604 (317)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Reproductive system status and the algorithm to solve fertility issues in men with cystic fibrosis

Alʹmanah Kliničeskoj Mediciny, 2019
Rationale: Cystic fibrosis (CF) is a common hereditary disease related to the CFTR gene mutations and characterized by progression and multiple system involvement (primarily of the digestive tract and / or pulmonary system).
S. A. Repina, S. A. Krasovskiy, G. V. Shmarina, M. I. Shtaut, E. K. Zhekayte, A. Yu. Voronkova, V. D. Sherman, E. I. Kondratyeva, V. B. Chernykh   +8 more
doaj   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

Corneal Refractive Surgery Considerations in Patients with Cystic Fibrosis and Cystic Fibrosis Transmembrane Conductance Regulator-Related Disorders

International Medical Case Reports Journal, 2022
Majid Moshirfar,1– 3 Alex H Brown,4 Christian A Sulit,4 Wyatt M Corbin,5 Yasmyne C Ronquillo,1 Phillip C Hoopes1 1Hoopes Vision Research Center, Hoopes Vision, Draper, UT, USA; 2John A.
Moshirfar M, Brown AH, Sulit CA, Corbin WM, Ronquillo YC, Hoopes PC   +5 more
doaj  

Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. [PDF]

, 2019
Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by many loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, including N1303K. We previously introduced the
Finkbeiner, Walter E, Haggie, Peter M, Nielson, Dennis W, Phuan, Puay-Wah, Rivera, Amber A, Tan, Joseph-Anthony, Verkman, Alan S, Zlock, Lorna   +7 more
core  

Temperature-dependent release of ATP from human erythrocytes: Mechanism for the control of local tissue perfusion [PDF]

, 2012
Copyright @ 2012 The AuthorsThis article has been made available through the Brunel Open Access Publishing Fund.Human limb muscle and skin blood flow increases significantly with elevations in temperature, possibly through physiological processes that ...
Abraham, Akyurekli, Baar, Barcroft, Bazett, Bergfeld, Black, Cheng, Coade, Cripps, Denning, Deussen, Dill, Duc, Dufour, Ellsworth, Feliciano, Fischer, González-Alonso, González-Alonso, González-Alonso, Gordon, Gorman, Gorman, Gourine, Green, He, José González-Alonso, Kameljit K. Kalsi, Keller, Kirby, Kirby, Llaudet, Locovei, Malinauskas, Mortensen, Mortensen, Mortensen, Niimi, Olearczyk, Pearson, Ray, Rosenmeier, Rowell, Ruiter, Saltin, Schrage, Scott-Ward, Sheppard, Sprague, Sprague, Sridharan, Sterling, Tu, Williamson, Yegutkin, Yegutkin, Zimmermann, Zimmermann   +58 more
core   +2 more sources

Soft Artificial Ciliary Brush with Integrated Haptic Feedback for Efficient Airway Mucus Cleaning

Advanced Intelligent Systems, EarlyView.
A fundamental mucus cleaning mechanism is reported, which utilizes both artificial cilia mechanical sweeping and suction‐based mucus cleaning. A novel haptic feedback interface for the artificial cilia provides touch feedback on tissue contact, enhancing operator control and safety.
Zhongming Lyu, Yusheng Wang, Ruijian Ge, Darren Wang, Matthew Bacchetta, Caitlin T. Demarest, Fabien Maldonado, Xiaoguang Dong   +7 more
wiley   +1 more source

Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury [PDF]

, 2019
Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation ...
Carpino, Guido, de Jong, Iris E M, Gaudio, Eugenio, Gouw, Annette S H, Iswandana, Raditya, Lisman, Ton, Matton, Alix P M, Olinga, Peter, Oosterhuis, Dorenda, Overi, Diletta, Porte, Robert J, Suriguga, Su, van Haaften, Wouter T, van Praagh, Jasper B, van Wijk, Louise A, Wiersema-Buist, Janneke   +15 more
core   +8 more sources

CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial Cells

Cells, 2022
People with cystic fibrosis should be considered at increased risk of developing severe symptoms of COVID-19. Strikingly, a broad array of evidence shows reduced spread of SARS-CoV-2 in these subjects, suggesting a potential role for CFTR in the ...
Virginia Lotti, Flavia Merigo, Anna Lagni, Andrea Di Clemente, Marco Ligozzi, Paolo Bernardi, Giada Rossini, Ercole Concia, Roberto Plebani, Mario Romano, Andrea Sbarbati, Claudio Sorio, Davide Gibellini   +12 more
doaj   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source