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Abstract 179: Histone deacetylase inhibitor; CG005, is a novel anticancer drug; as a combination drug with docetaxel in prostate cancer

open access: closedCancer Research, 2011
Abstract We synthesized a novel hydroxamate-based HDACi, CG0005 {(E)-2-(Naphthalen-1-yloxymethyl)-oct-2-enedioic acid 1-[(3-dimethylamino-propyl)-amide] 8-hydroxyamide]}. Like other inhibitors, for example SAHA and PXD 101, CG0005 has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. The aliphatic chain of CG0005,
Yong Sook Kim   +7 more
openalex   +2 more sources

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