Results 1 to 10 of about 11,902 (87)

Cardiovascular effects of sildenafil in hypertensive men with erectile dysfunction and different alleles of the type 5 cGMP-specific phosphodiesterase (PDE5) [PDF]

International Journal of Impotence Research, 2004
Erectile dysfunction (ED) is frequent in patients with essential hypertension (EH); a likely common pathogenetic pathway could be a reduced ability of arteriolar vascular smooth muscle (VSM) to relax. Increasing intracellular levels of cGMP reduce the contractile status of VSM; on the contrary, type 5 cGMP-specific phosphodiesterase (PDE5, codified by ...
F, Salvi, R, Sarzani, R, Giorgi, G, Donatelli, F, Pietrucci, A, Micheli, M, Baldoni, D, Minardi, D, Minaroli, P, Dessì-Fulgheri, M, Polito, G, Muzzonigro, A, Rappelli   +12 more
openaire   +3 more sources

Use of combination of mitral clip and CGMP-specific phosphodiesterase type 5 inhibitor as bridge for cardiac transplantation

Journal of the Saudi Heart Association, 2013
IntroductionSevere mitral regurgitation (MR) and severe pulmonary hypertension (PH) are common consequence of advanced end stage heart failure (HF). Cardiac transplantation is the only available treatment modality with reasonable long term outcome for end stage HF. Presence of severe resistant PH could preclude transplantation.
Almasood, Ali, Khairallah, Hatem, Shah, Aijaz, Alabdallah, Moheeb, Alotaibi, Mohamed, Al-Moghairi, Abdulrahman   +5 more
openaire   +2 more sources

Erratum: Cardiovascular effects of sildenafil in hypertensive men with erectile dysfunction and different alleles of type 5 cGMP-specific phosphodiesterase (PDE5) [PDF]

International Journal of Impotence Research, 2006
F Salvi, R Sarzani, R Giorgi, G Donatelli, F Pietrucci, A Micheli, M Baldoni, D Minardi, P Dessì-Fulgheri, M Polito, G Muzzonigro, A Rappelli   +11 more
openaire   +2 more sources

Role of Phosphodiesterase 1 in the Regulation of Real-Time cGMP Levels and Contractility in Adult Mouse Cardiomyocytes

Cells, 2023
In mouse cardiomyocytes, the expression of two subfamilies of the calcium/calmodulin-regulated cyclic nucleotide phosphodiesterase 1 (PDE1)—PDE1A and PDE1C—has been reported. PDE1C was found to be the major subfamily in the human heart.
Nadja I. Bork, Hariharan Subramanian, Roberta Kurelic, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +4 more
doaj   +1 more source

A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2

Microorganisms, 2021
The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in serious chaos all over the world.
Seri Jo, Suwon Kim, Jahyun Yoo, Mi-Sun Kim, Dong Hae Shin   +4 more
doaj   +1 more source

Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis. [PDF]

PLoS ONE, 2013
Morbi-mortality in cystic fibrosis (CF) is mainly related to chronic lung infection and inflammation, uncontrolled tissue rearrangements and fibrosis, and yet the underlying mechanisms remain largely unknown.
François Huaux, Sabrina Noel, Barbara Dhooghe, Nadtha Panin, Sandra Lo Re, Dominique Lison, Pierre Wallemacq, Etienne Marbaix, Bob J Scholte, Patrick Lebecque, Teresinha Leal   +10 more
doaj   +1 more source

Effects of PDE5 Inhibitors and sGC Stimulators in a Rat Model of Artificial Ureteral Calculosis. [PDF]

PLoS ONE, 2015
Urinary colics from calculosis are frequent and intense forms of pain whose current pharmacological treatment remains unsatisfactory. New and more effective drugs are needed to control symptoms and improve stone expulsion.
Peter Sandner, Hanna Tinel, Giannapia Affaitati, Raffaele Costantini, Maria Adele Giamberardino   +4 more
doaj   +1 more source

Evaluation of testosterone and prolactin hormones levels in erectile dysfunction patients after single oral dose of Tadalafil

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2008
Erectile dysfunction (ED) is defined as a consistent inability to sustain an erection sufficient for sexual intercourse. Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5 ...
Hayder Hamed Abed
doaj   +1 more source

In Silico Mapping of Essential Residues in the Catalytic Domain of PDE5 Responsible for Stabilization of Its Commercial Inhibitors

Scientia Pharmaceutica, 2019
Phosphodiesterase type 5 (PDE5) is an important enzyme associated with the hydrolysis of cyclic guanosine monophosphate (cGMP) to guanosine monophosphate (GMP).
Ivan Pires de Oliveira, Caroline Honaiser Lescano, Gilberto De Nucci   +2 more
doaj   +1 more source

Cardiac Rehabilitation and resuming sexual activity

Monaldi Archives for Chest Disease, 2004
patients’ quality of life and subjective well being. Patients, however, are often uninformed regarding the question of resuming sexual activity after a cardiac event.
Duilio Tuniz, Enzo Petri, Maurizio Carone, Guglielmo Bernardi, Paolo M. Fioretti   +4 more
doaj   +1 more source