Results 31 to 40 of about 12,060 (105)

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management

Rheumatology &Autoimmunity, Volume 6, Issue 1, Page 16-38, March 2026.
Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley   +1 more source

Erectile and ejaculatory outcomes after holmium laser enucleation of the prostate: A comprehensive narrative review

UroPrecision, Volume 4, Issue 1, Page 3-13, March 2026.
ABSTRACT Holmium laser enucleation of the prostate (HoLEP) has emerged as a widely adopted surgical technique for the management of benign prostatic hyperplasia (BPH), regardless of prostate size; however, its impact on male sexual function—particularly in terms of erectile and ejaculatory outcomes—remains a subject of ongoing debate.
Muhammed Arif İbiş, Fabio Castiglione, Nawal Khan, Ömer Onur Çakır, Zafer Tokatlı, Önder Yaman   +5 more
wiley   +1 more source

Erratum: Cardiovascular effects of sildenafil in hypertensive men with erectile dysfunction and different alleles of type 5 cGMP-specific phosphodiesterase (PDE5) [PDF]

International Journal of Impotence Research, 2006
F Salvi, R Sarzani, R Giorgi, G Donatelli, F Pietrucci, A Micheli, M Baldoni, D Minardi, P Dessì-Fulgheri, M Polito, G Muzzonigro, A Rappelli   +11 more
openaire   +1 more source

Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review. [PDF]

Medicine (Baltimore)
Alnazari M, Bakhsh A, Abdullah S, Al Qahtani S, Borhan W, Rajih E, Alshehri AM.   +6 more
europepmc   +1 more source

Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential. [PDF]

Bone Rep
Ursachi VC, Horak J, Fafilek B.
europepmc   +1 more source

Clinical and Functional Characterization of PDE1A as a Wnt/<b>β</b>-Catenin-Linked Biomarker of Progression and Platinum Resistance in Epithelial Ovarian Cancer. [PDF]

Oncol Res
Han GH, Yun H, Chung JY, Kim JH, Cho H.
europepmc   +1 more source

Anti-Inflammatory and Anti-apoptotic Effects of Phosphodiesterase Inhibitors Against Streptozocin-induced Diabetic Nephropathy. [PDF]

In Vivo
Mehanna OM, Elesawy BH, Elaskary A, Hassan MGM, Ahmed WMS, El Monsef ASA, Abbas MAM, Hammad AM, Elgazzar UB, Gabr NM, El-Sharnouby M, Sharahili AI, Khalifa MM.   +12 more
europepmc   +1 more source

Intercellular diffusion of cyclic nucleotides followed by gap junction closure restarts meiosis in mouse preovulatory follicles. [PDF]

Proc Natl Acad Sci U S A
Nakashima IF, Zhong H, Nikolaev VO, Owen CM, Yee SP, Jaffe LA, Egbert JR.   +6 more
europepmc   +1 more source

PDE10A as a novel diagnostic and therapeutic target in cancer: insights and challenges. [PDF]

Front Oncol
Ghoflchi S, Nakhaei A, Abbasinezhad-Moud F, Jalili-Nik M, Cimino PJ.   +4 more
europepmc   +1 more source