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Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites

American Journal of Physiology-Renal Physiology, 2005
In the present study, we tested the hypothesis that inhibition of renal phosphodiesterase type 5 (PDE5) in patients with liver cirrhosis and ascites increases sodium excretion. The effect of sildenafil citrate was studied in a randomized double-blind. placebo-controlled crossover study.
Thiesson, Helle   +8 more
openaire   +5 more sources

Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

Nature Reviews Drug Discovery, 2023
P V Kolkhir   +2 more
exaly  

Type VII secretion systems: structure, functions and transport models

Nature Reviews Microbiology, 2021
Angel Rivera-Calzada   +2 more
exaly  

Targeting inflammation in the treatment of type 2 diabetes: time to start

Nature Reviews Drug Discovery, 2014
Marc Y Donath
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Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes

Nature Reviews Drug Discovery, 2011
Frank D Waldron-Lynch, Kevan C Herold
exaly  

Type IV pilus structure and bacterial pathogenicity

Nature Reviews Microbiology, 2004
Lisa Craig, John A Tainer
exaly  

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