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Characterization of novel rhodopsins with light-regulated cGMP production or cGMP degradation [PDF]
Photorezeptoren sind in fast allen Lebewesen vorzufinden. Sie vermitteln den ersten Schritt bei der Detektion von elektromagnetischer Strahlung unterschiedlicher Wellenlänge. Ihre Absorptionsspektren finden sich innerhalb des Bereichs der stärksten Sonnenstrahlung (UV bis nahes IR) und die Absorption löst normalerweise nachgelagerte Signalwege aus. Bis
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NO/cGMP: The Past, the Present, and the Future
2013The NO/cGMP signalling cascade participates in the regulation of physiological parameters such as smooth muscle relaxation, inhibition of platelet aggregation, and neuronal transmission. cGMP is formed in response to nitric oxide (NO) by NO-sensitive guanylyl cyclases that exist in two isoforms (NO-GC1 and NO-GC2).
Michael Russwurm+3 more
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Dynamics of cellular NO-cGMP signaling
Frontiers in Bioscience, 2005Despite its widespread biological importance, knowledge about the basic workings of the nitric oxide (NO) signaling pathway at the cellular level has been unsatisfactory. As reviewed here, recent findings have begun to rectify this deficiency. Elementary NO signals may be very discrete, being short lived (seconds or less), of low amplitude (peak ...
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2004
Chemistry, Manufacturing and Controls (CMC) is the body of information that includes the manufacturing, testing, and release of product. Good manufacturing practices are the actual requirements that need to be followed to ensure that the product meets its intended characteristics.
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Chemistry, Manufacturing and Controls (CMC) is the body of information that includes the manufacturing, testing, and release of product. Good manufacturing practices are the actual requirements that need to be followed to ensure that the product meets its intended characteristics.
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Increased cGMP promotes healthy expansion and browning of white adipose tissue
The FASEB Journal, 2013M. Mitschke+9 more
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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.
Current Opinion in Cell Biology, 2000S. Soderling, J. Beavo
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