Results 101 to 110 of about 39,366 (261)

The relationship between self-esteem and procrastination among university students: the chain mediating effect of perfectionism and academic motivation

Frontiers in Psychology
BackgroundProcrastination among university students has adverse effects on their academic performance, daily life, and physical and mental health.
Chunmei Chen, Dandan Chen, Yujie Zhu, Fanghao Xiao, Yanlong Li, Xinxin Lin   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Use of Semantic Mediation in Manufacturing Supply Chains

, 2010
This chapter discusses lessons learned about enabling interoperability using semantic methods in three automotive industry projects spanning 8 years. In these projects the authors attempt to automate systems integration tasks typically performed manually. The essential form of the solution is to define ontologies of (1) the joint action of the required
Peter Denno, Edward J. Barkmeyer, Fabian Neuhaus   +2 more
openaire   +2 more sources

The relationship between structural campus climate and non-suicidal self-injury among middle school students: the chain-mediated roles of physical exercise and school bullying

Frontiers in Psychology
BackgroundA structural campus climate (SCC) represents the organizational and orderly dimension of school climate. A high level of SCC means that a school possesses fair rules, reasonable value systems, and safety guarantees, all of which are key factors
Yang Zhou
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Physical activity and alexithymia: chain mediation of sense of coherence and social anxiety—a study of chemistry majors

Frontiers in Psychology
AimThis study aimed to explore the effect of physical activity on alexithymia and to establish a chain mediation model with sense of coherence and social anxiety as mediators.
Yang Lv, Yang Liu
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Digital literacy and creative teaching behavior among nursing educators: the chain mediating roles of self-efficacy and digital stress

Frontiers in Psychology
BackgroundThe rapid digital transformation of nursing education has placed increasing demands on nurse educators, yet the psychological mechanisms linking digital literacy to creative teaching behavior remain poorly understood.ObjectivesThis study aimed ...
Wu Chong-Wen, Song Jin, Shasha Li, Zou Xiaoyue, Qu Baifeng, Wang Rui   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The relationship between self-connection and online prosocial behavior among college students: the chain mediating roles of belief in a just world and meaning in life

Frontiers in Psychology
ObjectiveThis study aimed to explore the relationship between self-connection and online prosocial behavior among college students, and to examine the mediating roles of belief in a just world and meaning in life.MethodsA total of 1,303 college students ...
Xia Cai, Xinyu Liu, Xiangcai He, Xiangcai He   +3 more
doaj   +1 more source