Results 41 to 50 of about 39,366 (261)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A chain mediation model for physical exercise and sleep quality. [PDF]

Sci Rep
In recent years, there has been a significant increase in academic interest regarding the sleep quality of university students. Physical exercise has been extensively studied for its association with sleep quality in this population. However, the roles of anxiety and subjective well-being in mediating the relationship between physical exercise and ...
Zhu Y, Zhang Q, Zhu P, Dong Y, Tan L, Liu P, Yi Z.   +6 more
europepmc   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mediators or Alternative Explanations: Transitivity in Human-Mediated Causal Chains [PDF]

, 2015
We investigate how learning that an established type-level causal relationship is implemented by human agency affects people’s conceptualization of this relationship. In particular, we ask under what conditions subjects continue to perceive the original root cause as appropriate explanation for the resulting effect, and under what conditions they ...
Nagel, Jonas, Stephan, Simon
openaire  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Direct and respiratory chain-mediated redox cycling of adrenochrome

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1990
Adrenochrome is reduced by ascorbate in a reaction accompanied by a large and rapid oxygen uptake. The rates of adrenochrome reduction and the concomitant oxygen uptake are decreased in the presence of superoxide dismutase or catalase. The species formed on the one-electron reduction of adrenochrome (i.e., the semiquinone) was shown by pulse radiolysis
BINDOLI, ALBERTO, Deeble D. J., RIGOBELLO, MARIA PIA, GALZIGNA, LAURO   +3 more
openaire   +3 more sources

Carbon Chain Decomposition of Short Chain Chlorinated Paraffins Mediated by Pumpkin and Soybean Seedlings [PDF]

Environmental Science & Technology, 2019
Short chain chlorinated paraffins (SCCPs) are a group of complex emerging persistent organic pollutants. In this study, the uptake, translocation, and transformation of four constitutionally defined SCCP isomers were studied using whole pumpkin ( Cucurbita maxima × C. moschata) and soybean ( Glycine max L.
Yanlin Li, Xingwang Hou, Weifang Chen, Jiyan Liu, Qunfang Zhou, Jerald L. Schnoor, Guibin Jiang   +6 more
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Psychological capital and pre-competition anxiety among adolescent basketball players: the chain mediating roles of mental fatigue and achievement motivation

Frontiers in Psychology
ObjectiveThis study aimed to explore the association mechanism between psychological capital and pre-competition anxiety in adolescent basketball players, and to verify the independent and chain mediating roles of mental fatigue and achievement ...
Xuefeng Liu, Qian Ge, Heng Liu
doaj   +1 more source