Results 71 to 80 of about 39,366 (261)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The impact of family environment on social avoidance in adolescents with depressive disorders: a chain mediation model involving basic psychological needs and core self-evaluations

Frontiers in Psychiatry
BackgroundSocial avoidance is a critical barrier to functional recovery among adolescents with depressive disorders. Although family environment is recognized as a key contextual factor, the psychological mechanisms linking family environment to social ...
Xin Tian, Xin Tian, Liqi Gu, Xinrong Ma, Yuelan Zhang, Ling Dang, Furong Gou, Mengyuan Zhang, Wenjun Wang, Hao Duan   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The impact of proactive personality on career choice anxiety among university students: the chain mediating roles of intolerance of uncertainty and career decision making difficulties

Frontiers in Psychology
ObjectiveBased on the theoretical frameworks of social cognitive career theory and cognitive-behavioral theory, this study aimed to construct a chain mediation model to explore the impact of proactive personality on career choice anxiety among university
Na Li, Jinlou Xie, Zhengchun Guo, Yinnan Yang   +3 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

The impact of professional mission on turnover intention among operating room nurses: a chain mediation model analysis of professional identity and job burnout

BMC Psychology
Background and aim To investigate the chain mediation effect of professional mission, professional identity, and job burnout on the turnover intention among operating room nurses.
Guangying Liu, Hong Qi, Fuwen Hou, Kexin Qi, Xiaoli Luan   +4 more
doaj   +1 more source

The chain mediating role of rumination and psychological resilience in symptom burden and kinesiophobia in patients with chronic heart failure

Frontiers in Psychiatry
ObjectiveTo explore the chain-mediating role and impact of rumination and psychological resilience on symptom burden and kinesiophobia in patients with chronic heart failure.MethodsWe selected a total of 318 patients with chronic heart failure from a ...
Mengqi Li, Mengqi Li, Lina Cheng, Yu Jiang   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The impact of physical education teacher support on sport participation among college students: the chain mediating effects of physical education learning motivation and self-efficacy

Frontiers in Psychology
ObjectiveThis study aimed to examine the relationship between physical education (PE) teacher support and sport participation among college students, with a particular focus on the mediating roles of PE learning motivation and self-efficacy.MethodsA ...
Wenquan Su, Qiang Liu
doaj   +1 more source