S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes. [PDF]
Front Immunol, 2021 Nakagawa T +11 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
The Integration Functions of Topic Chains in Chinese Discourse
Acta Linguistica Asiatica, 2019 The topic chain, one of the essential organization devices in Chinese discourse, is highlighted by the use of many co-referential zero forms. Although the topic chain has been realized to play an important role in organizing discourse, few attempts have
Kun SUN
doaj +1 more source
Resonant transmission of light through finite chains of subwavelength holes
, 2004 In this paper we show that the extraordinary optical transmission phenomenon found before in 2D hole arrays is already present in a linear chain of subwavelength holes, which can be considered as the basic geometrical unit showing this property. In order
A. Roberts +7 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Trust chain generating and updating algorithm for dual redundancy system
Tongxin xuebao, 2017 In trusted computing field,the traditional construction mode of trust chain is only applicable to a single system.For the dual redundancy system,it causes break of transitive trust.A trust model suitable for dual redundancy system was proposed.Through ...
Lei WANG +3 more
doaj +2 more sources
Model based methodology development for energy recovery in ash heat exchange systems [PDF]
, 2010 Flash tank evaporation combined with a condensing heat exchanger can be used when heat exchange is required between two streams and where at least one of these streams is difficult to handle (in terms of solid particles content, viscosity, pH ...
Korobeinikov, A. +7 more
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Type Synthesis of Hybrid Robot Mechanism with 3T2R based on Single Opened Chain Unit
Jixie chuandong, 2016 By analyzing the structures characteristics of the lower- mobility serial kinematic mechanism（SKM） and parallel kinematic mechanism（ PKM）,based on the linear independence theory of kinematic screws and taking of the lower- mobility SKM with single opened
Sheng Weifeng +3 more
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